About: Recombinant Fowlpox-PSA(L155)/TRICOM Vaccine     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Recombinant Fowlpox-PSA(L155)/TRICOM Vaccine
rdfs:subClassOf
Has_Target
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Recombinant Fowlpox-PSA(L155)/TRICOM Vaccine
NSC_Code
  • 717171
UMLS_CUI
  • C1515688
PDQ_Open_Trial_Search_ID
  • 305933
PDQ_Closed_Trial_Search_ID
  • 305933
Legacy_Concept_Name
  • rFowlpox-PSA_L155_TRICOM
FULL_SYN
  • rFowlpox-PSA(L155)/TRICOM VaccineSYNCI
  • Recombinant Fowlpox-PSA(L155)/TRICOM VaccinePTNCI
  • PROSTVAC-FSYNCI
DEFINITION
  • A cancer vaccine consisting of a recombinant fowlpox virus encoding fragment of human prostate-specific antigen (PSA), PSA:154-163 (155L), and a TRIad of COstimulatory Molecules (B7-1, ICAM-1 and LFA-3) (TRICOM). Administration of this agent may induce a cytotoxic T cell response against PSA-expressing tumor cells. Dendritic cells infected with TRICOM vectors greatly enhance naive T-cell activation and peptide-specific T-cell stimulation. Fowlpox virus is an attractive vector because its genome is easy to manipulate and it is replication incompetent in mammalian cells.NCI
code
  • C29560
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