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AttributesValues
rdf:type
rdfs:label
  • Racemic XK469
rdfs:subClassOf
Has_Target
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Racemic XK469
NSC_Code
  • 698215
UMLS_CUI
  • C1611867
CAS_Registry
  • 157542-91-1
PDQ_Open_Trial_Search_ID
  • 440966
PDQ_Closed_Trial_Search_ID
  • 440966
Legacy_Concept_Name
  • XK469R
FULL_SYN
  • XK469 RacemicSYNCI
  • Racemic XK469PTNCI
  • XK469RCNNCI
  • Propanoic acid, 2-[4-[(7-chloro-2-quinoxalinyl)oxy]-phenoxy]-, (+ /-)-SNNCI
DEFINITION
  • The racemic form of a synthetic quinoxaline phenoxypropionic acid derivative with antineoplastic properties. XK469R selectively inhibits topoisomerase II by stabilizing the enzyme-DNA intermediates in which topoisomerase subunits are covalently linked to DNA through 5-phosphotyrosyl linkages, thereby interfering with DNA repair and replication, RNA and protein synthesis. This agent possesses unusual solid tumor selectivity and activity against multidrug-resistant cancer cells. XK469R is more water soluble and active than the pure isomers, R(+)XK469 and S(-)XK469. (NCI05)NCI
code
  • C2825
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