About: ALVAC-hB7.1     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • ALVAC-hB7.1
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
  • Immunologic Factor
Preferred_Name
  • ALVAC-hB7.1
NSC_Code
  • 674306
UMLS_CUI
  • C0796294
In_Clinical_Trial_For
  • Melanoma
PDQ_Open_Trial_Search_ID
  • 42860
PDQ_Closed_Trial_Search_ID
  • 42860
Legacy_Concept_Name
  • ALVAC-hB7_1
FULL_SYN
  • ALVAC-hB7.1PTNCI
DEFINITION
  • A vaccine comprise of a canarypox viral vector that carries the gene for human B7.1 (CD80 antigen) with potential use as an autologous therapeutic cancer vaccine. Tumor cells harvested from a patient are infected with ALVAC-hB7 1, thereby producing an autologous cell line that exhibits increased expression of HLA class I and class II, CD54 (ICAM), and CD80. Increased expression of these proteins by this autologous cell line may activate an antitumor T-cell response when the modified cells are administered to the patient. (NCI04)NCI
code
  • C2485
is someValuesFrom of
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