About: cAMP Responsive Element Binding Protein

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Attributes	Values
rdf:type	Class
rdfs:label	cAMP Responsive Element Binding Protein
rdfs:subClassOf	Transcription Factors nodeID://b725763 nodeID://b725764 nodeID://b725765 nodeID://b725766 nodeID://b725767 nodeID://b725768
Semantic_Type	Amino Acid, Peptide, or Protein
Preferred_Name	cAMP Responsive Element Binding Protein
UMLS_CUI	C0056695
ALT_DEFINITION	family of transcription factors that stimulate transcription of target genes in response to hormonal signals that elevate intracellular cAMP levels.CSP2000
Legacy_Concept_Name	cAMP_Responsive_Element_Binding_Protein
FULL_SYN	CREBSYNCI CREB ProteinSYNCI Cyclic AMP Responsive Element Binding ProteinSYNCI cAMP Responsive Element Binding ProteinPTNCI CRE Binding ProteinSYNCI
DEFINITION	Ubiquitously or widely expressed human cAMP Responsive Element Binding Proteins (bZIP/CREB Family) are conserved nuclear bZIP domain dimeric transcription factors that bind to octameric DNA palindrome cAMP-response elements (CRE) present in many viral and cellular promoters and induce gene transcription in response to cAMP signaling pathways. CREB proteins bind to DNA as a homodimer or a heterodimer with JUN/c-Jun or ATF2/CREBP1. Increased cAMP levels following stimulation activate cAMP-dependent protein kinase A, which phosphorylates CREB proteins that stimulate transcription of cAMP-responsive genes. Calcium-regulated CREB transcription factors integrate calcium and cAMP signals. cAMP pathways provide a chief means by which cellular growth, differentiation, and function can be influenced by extracellular signals. (NCI)NCI
code	C17286
is rdf:first of	nodeID://b737829 nodeID://b737830 nodeID://b737831 nodeID://b737832 nodeID://b737833 nodeID://b737834 nodeID://b737835 nodeID://b737836 nodeID://b737837 nodeID://b737838 nodeID://b737839 nodeID://b737840

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