About: Ammonium Trichlorotellurate     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Ammonium Trichlorotellurate
rdfs:subClassOf
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Ammonium Trichlorotellurate
NSC_Code
  • 618654
UMLS_CUI
  • C1706673
CAS_Registry
  • 106566-58-9
PDQ_Open_Trial_Search_ID
  • 41938
PDQ_Closed_Trial_Search_ID
  • 41938
Legacy_Concept_Name
  • Ossirene
FULL_SYN
  • Tellurate(1-), trichloro[1,2-ethanediolato(2-)-.kappa.O,.kappa.O']-,ammonium, (SP-5-22)-SNNCI
  • Ammonium TrichlorotelluratePTNCI
  • AS-101CNNCI
  • OssireneBRNCI
  • IVX-Q-101CNNCI
DEFINITION
  • A synthetic non-toxic tellurium derivative, structurally similar to cisplatin, with immunostimulatory and anti-hair loss properties. Ammonium trichlorotellurate induces production of colony stimulating factor (CSF), interleukin-2 (IL-2), and IL-2 receptors by increasing the calcium ion influx through the cell membrane and subsequently exerts its immunostimulatory effects through the CSF-mediated increase in macrophage/granulocytes. This agent is also a potent inducer of interferon and a spectrum of cytokines such as IL-1, IL-6, and tumor necrosis factor (TNF). In animal studies, ammonium trichlorotellurate exerts its anti-hair loss effect by inducing anagen and obstructing spontaneous catagen via promoting follicular keratinocyte proliferation and interfering with terminal differentiation, respectively.NCI
DesignNote
  • Although its CN is AS101, it's not the same as 4-Arsanilic acid, NSC 2023, (C29883).
code
  • C1006
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