About: Dimethyl fumarate

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

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http://linked.open...gbank/description	Dimethyl fumarate is an anti-inflammatory. It is indicated for multiple sclerosis patients with relapsing forms and is also being investigated for the treatment of psoriasis. The mechanism of action of dimethyl fumarate in multiple sclerosis is not well understood. It is thought to involve dimethyl fumarate degradation to its active metabolite monomethyl fumarate (MMF) then MMF up-regulates the Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) pathway that is activated in response to oxidative stress. Dimethyl fumarate is marketed under the brand name Tecfidera. (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B5C3B-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5C3C-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5C3D-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5C3E-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5C3F-363D-11E5-9242-09173F13E4C5
http://linked.open...generalReferences	# Papadopoulou A, D'Souza M, Kappos L, Yaldizli O: Dimethyl fumarate for multiple sclerosis. Expert Opin Investig Drugs. 2010 Dec;19(12):1603-12. doi: 10.1517/13543784.2010.534778. Epub 2010 Nov 11. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/21067468 # FDA label. (en)
http://linked.open...gy/drugbank/group	approved (en) investigational (en)
http://linked.open...drugbank/halfLife	MMF has a short half life of about 1 hour, and MMF does not accumulate after repeated doses of dimethyl fumarate. (en)
http://linked.open...ugbank/indication	Used in multiple sclerosis patients with relapsing forms. (en)
sameAs	Dimethyl fumarate
Title	Dimethyl fumarate (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB08908/identifier/drugbank/DB08908 http://linked.opendata.cz/resource/drugbank/drug/DB08908/identifier/national-drug-code-directory/64406-006-02 http://linked.opendata.cz/resource/drugbank/drug/DB08908/identifier/wikipedia/Dimethyl_fumarate
http://linked.open...mechanismOfAction	The mechanism of action of dimethyl fumarate in multiple sclerosis is not well understood. It is thought to involve dimethyl fumarate degradation to its active metabolite monomethyl fumarate (MMF). MMF up-regulates the Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) pathway that is activated in response to oxidative stress. As well MMF is an agonist at the nicotinic acid receptor, but the relevance of this is not known. (en)
http://linked.open...outeOfElimination	The main route of elimination is by CO2 exhalation that accounts for 60% of the dose. The other minor routes are through the kidney (16% metabolites and trace amounts of unchanged MMF) and the feces (1%). (en)
http://linked.open.../drugbank/synonym	(e)-But-2-enedioic acid dimethyl ester (en) 1,2-Bis(methoxycarbonyl)-trans-ethylene (en) BG-12 (en) Dimethyl trans-ethylenedicarboxylate (en) Fumaric acid, dimethyl ester (en) Tecfidera (en) dimethyl (E) butenedioate (en) trans-1,2-Ethylenedicarboxylic acid dimethyl ester (en) trans-Butenedioic acid dimethyl ester (en)
http://linked.open...drugbank/toxicity	The most common side effects observed were nausea, diarrhea, abdominal pain, and flushing. (en)
http://linked.open...umeOfDistribution	In healthy people, MMF has a variable volume of distribution of 53 to 73 litres. (en)
http://linked.open...k/foodInteraction	Food does not affect the pharmacokinetics of dimethyl fumarate, but it may reduce dimethyl fumarate induced GI upset and flushing. (en)
http://linked.open...nk/proteinBinding	MMF has a plasma protein binding range of 27 to 45%, and the binding is concentration independent. (en)
foaf:page	http://www.drugs.com/cdi/dimethyl-fumarate.html http://www.rxlist.com/tecfidera-drug.htm
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http://linked.open...l/drug/hasATCCode	Dimethyl fumarate
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http://linked.open...ugbank/absorption	Once ingested, dimethyl fumarate is rapidly hydroylyzed by esterases to MMF. Thus there is negligible amount of dimethyl fumarate in the body, and all pharmacokinetic information is quantified with MMF. In multiple sclerosis patients, the time to maximum concentration of MMF is 2 to 2.5 hours and the maximum concentration is 1.87 mg/L. (en)
http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	624-49-7 (en)
http://linked.open...drugbank/category	(en)
http://linked.open...rugbank/clearance	MMF clearance was not quantified. (en)
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