About: Peginesatide     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

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http://linked.open...gbank/description
  • Peginesatide is a synthetic peptide attached to polyethylene glycol for the treatment of anemia. The polyethylene glycol moiety helps make the drug less immunogenic and prolongs its plasma half-life. Chemically, peginesatide is designed to mimic the pharmacological activity of erythropoietin, but is not a replica of the structure itself. Peginesatide consists of two 21-amino acid chains that are covalently bonded by a linker derived from iminodiacetic acid and β-alanine. FDA approved March 27, 2012. (en)
http://linked.open...generalReferences
  • # Schmid H: Peginesatide for the treatment of renal disease-induced anemia. Expert Opin Pharmacother. 2013 May;14(7):937-48. doi: 10.1517/14656566.2013.780695. Epub 2013 Mar 18. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/23506424 # Woodburn KW, Holmes CP, Wilson SD, Fong KL, Press RJ, Moriya Y, Tagawa Y: Absorption, distribution, metabolism and excretion of peginesatide, a novel erythropoiesis-stimulating agent, in rats. Xenobiotica. 2012 Jul;42(7):660-70. doi: 10.3109/00498254.2011.649310. Epub 2011 Dec 22. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/22188389 # Woodburn KW, Fong KL, Wilson SD, Sloneker S, Strzemienski P, Solon E, Moriya Y, Tagawa Y: Peginesatide clearance, distribution, metabolism, and excretion in monkeys following intravenous administration. Drug Metab Dispos. 2013 Apr;41(4):774-84. doi: 10.1124/dmd.112.048033. Epub 2013 Jan 14. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/23318685 (en)
http://linked.open...gy/drugbank/group
  • approved (en)
http://linked.open...drugbank/halfLife
  • IV dose, healthy subjects = 25.0 ± 7.6 hours; SubQ, healthy subjects = 53.0 ± 17.7 hours; IV dose, dialysis patients = 47.9 ± 16.5 hours; (en)
http://linked.open...ugbank/indication
  • Peginesatide is used for the treatment of anemia due to chronic kidney disease (CKD) in adult patients on dialysis (en)
sameAs
Title
  • Peginesatide (en)
adms:identifier
http://linked.open...mechanismOfAction
  • Peginesatide binds to and activates the human erythropoietin receptor and stimulates erythropoiesis in human red cell precursors in vitro. (en)
http://linked.open...y/drugbank/patent
http://linked.open...outeOfElimination
  • Peginesatide administered intravenously or subcutaneously is primarily excreted via urine. Most of the excreted dose is in the form of unchanged drug. Elimination from the plasma is biphasic and rapid from vascular compartments. In contrast, the drug is selectively retained in sites of erythropoiesis like the bone marrow. (en)
http://linked.open.../drugbank/synonym
  • Erythropoiesis-Stimulating Agent (ESA) (en)
  • Hematide (en)
http://linked.open...drugbank/toxicity
  • The most common adverse events (≥10%) are dyspnea, diarrhea, nausea, cough, and arteriovenous fistula site complication. (en)
http://linked.open...umeOfDistribution
  • IV dose, dialysis patients = 34.9 ± 13.8 mL/kg; (en)
http://linked.open.../drug/hasAHFSCode
http://linked.open...nk/proteinBinding
  • Peginesatide does not bind to serum albumin or lipoprotein as demonstrated in in-vitro studies. (en)
http://linked.open...ogy/drugbank/salt
  • (en)
foaf:page
http://linked.open...Molecular-Formula
http://linked.open...logy/drugbank/pKa
http://linked.open...l/drug/hasATCCode
http://linked.open...ugbank/absorption
  • Tmax, SubQ dose = 48 hours; Bioavailability, SubQ dose = 46%; Peginesatide does not accumulate when administered every 4 weeks following intravenous or subcutaneous administration. (en)
http://linked.open.../affectedOrganism
  • Humans and other mammals (en)
http://linked.open...casRegistryNumber
  • 913976-27-9 (en)
http://linked.open...drugbank/category
  • (en)
http://linked.open...rugbank/clearance
  • Systemic clearance, IV dose, dialysis patients = 0.5 ± 0.2 mL/hr•kg (en)
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