About: gabapentin enacarbil

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	Gabapentin enacarbil is marketed under the name Horizant®. It is a prodrug of gabapentin, and indicated in adults for the treatment of Restless Legs Syndrome (RLS) and postherpetic neuralgia (PHN). (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B59BF-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B59C0-363D-11E5-9242-09173F13E4C5
http://linked.open...generalReferences	# Cundy KC, Annamalai T, Bu L, De Vera J, Estrela J, Luo W, Shirsat P, Torneros A, Yao F, Zou J, Barrett RW, Gallop MA: XP13512 [(+/-)-1-([(alpha-isobutanoyloxyethoxy)carbonyl] aminomethyl)-1-cyclohexane acetic acid], a novel gabapentin prodrug: II. Improved oral bioavailability, dose proportionality, and colonic absorption compared with gabapentin in rats and monkeys. J Pharmacol Exp Ther. 2004 Oct;311(1):324-33. Epub 2004 May 14. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/15146029 (en)
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...drugbank/halfLife	The elimination half-life of gabapentin is 5.1 to 6.0 hours. (en)
http://linked.open...ugbank/indication	For the treatment of adult Restless Legs Syndrome (RLS) and postherpetic neuralgia (PHN). (en)
sameAs	gabapentin enacarbil
Title	gabapentin enacarbil (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB08872/identifier/chebi/68840 http://linked.opendata.cz/resource/drugbank/drug/DB08872/identifier/drugbank/DB08872 http://linked.opendata.cz/resource/drugbank/drug/DB08872/identifier/kegg-drug/D09539 http://linked.opendata.cz/resource/drugbank/drug/DB08872/identifier/wikipedia/Gabapentin_enacarbil
http://linked.open...mechanismOfAction	Although the exact mechanism of action of gabapentin in RLS and PHN is unknown, it is presumed to involve the descending noradrenergic system, resulting in the activation of spinal alpha2-adrenergic receptors. (en)
http://linked.open...outeOfElimination	Gabapentin enacarbil is eliminated primarily in the urine (94%) and to a lesser extent in the feces (5%). (en)
http://linked.open.../drugbank/synonym	XP13512 (en) Gabapentina enacarbilo (en) Gabapentine enacarbil (en) Gabapentinum enacarbilum (en) Horizant (en) XP 13512 (en) XP-13512 (en)
http://linked.open...drugbank/toxicity	Most common adverse reactions are headache, dizziness, and somnolence. (en)
http://linked.open...umeOfDistribution	The volume of distribution is 76L. (en)
http://linked.open...k/foodInteraction	No food effects. (en)
http://linked.open...nk/proteinBinding	Gabapentin plasma protein binding is less than 3%. (en)
http://linked.open...ynthesisReference	1. Cundy KC, Branch R, Chernov-Rogan T, Dias T, Estrada T, Hold K, Koller K, Liu X, Mann A, Panuwat M, Raillard SP, Upadhyay S, Wu QQ, Xiang JN, Yan H, Zerangue N, Zhou CX, Barrett RW, Gallop MA: XP13512 [(+/-)-1-([(alpha-isobutanoyloxyethoxy)carbonyl] aminomethyl)-1-cyclohexane acetic acid], a novel gabapentin prodrug: I. Design, synthesis, enzymatic conversion to gabapentin, and transport by intestinal solute transporters. J Pharmacol Exp Ther. 2004 Oct;311(1):315-23. Epub 2004 May 14. (en)
foaf:page	http://www.drugs.com/sfx/gabapentin-enacarbil-side-effects.html http://www.rxlist.com/horizant-drug.htm
http://linked.open.../Water-Solubility	http://linked.opendata.cz/resource/drugbank/property/271B59C1-363D-11E5-9242-09173F13E4C5
http://linked.open...logy/drugbank/pKa	http://linked.opendata.cz/resource/drugbank/property/271B59C3-363D-11E5-9242-09173F13E4C5
http://linked.open...ugbank/absorption	Gabapentin enacarbil is absorbed in the intestines by active transport through the proton-linked monocarboxylate transporter, MCT-1. (en)
http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	478296-72-9 (en)
http://linked.open...rugbank/clearance	Renal clearance of gabapentin is 5 to 7 L/hr. (en)
http://linked.open...ank/Melting-Point	http://linked.opendata.cz/resource/drugbank/property/271B59C2-363D-11E5-9242-09173F13E4C5

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