About: Brentuximab vedotin

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	Brentuximag vedotin or Adcetris® is an antibody-drug conjugate that combines an anti-CD30 antibody and the drug monomethyl auristatin E (MMAE). It is an anti-neoplastic agent used in the treatment of Hodgkin lymphoma and systemic anaplastic large cell lymphoma. Brentuximag vedotin was approved in 2011, and in January 2012, the drug label was revised to include a boxed warning of progressive multifocal leukoencephalopathy and death following JC virus infection. (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B599F-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B59A0-363D-11E5-9242-09173F13E4C5
http://linked.open...generalReferences	# Francisco JA, Cerveny CG, Meyer DL, Mixan BJ, Klussman K, Chace DF, Rejniak SX, Gordon KA, DeBlanc R, Toki BE, Law CL, Doronina SO, Siegall CB, Senter PD, Wahl AF: cAC10-vcMMAE, an anti-CD30-monomethyl auristatin E conjugate with potent and selective antitumor activity. Blood. 2003 Aug 15;102(4):1458-65. Epub 2003 Apr 24. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/12714494 (en)
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...drugbank/halfLife	The terminal half-life is 4-6 days. (en)
http://linked.open...ugbank/indication	Used in the treatment of Hodgkin lymphoma and systemic anaplastic large cell lymphoma. (en)
sameAs	Brentuximab vedotin
Title	Brentuximab vedotin (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB08870/identifier/drugbank/DB08870 http://linked.opendata.cz/resource/drugbank/drug/DB08870/identifier/kegg-drug/D09587 http://linked.opendata.cz/resource/drugbank/drug/DB08870/identifier/wikipedia/Brentuximab_vedotin
http://linked.open...mechanismOfAction	Brentuximab vedotin is composed of 3 parts: a chimeric human-murine IgG1 that targets CD30, monomethyl auristatin E (MMAE),which is a microtubule disrupting agent, and a protease-susceptible linker that covalently links the antibody and MMAE. The IgG1 antibody enables brentuximab vedotin to target tumor cells expressing CD30 on their cell surface then brentuximab vedotin gets internalized into the cell. Once inside, the linker is cleaved releasing MMAE which binds disrupts the microtuble network. (en)
http://linked.open...outeOfElimination	MMAE is eliminated by the feces (with 72% unchanged) and urine. (en)
http://linked.open.../drugbank/synonym	cAC10-vcMMAE (en)
http://linked.open...drugbank/toxicity	The most severe toxic reaction seen in patients is progressive multifocal leukoencephalopathy. Other toxicities include bone marrow suppression, infusion reactions, peripheral neuropathy, Stevens-Johnson syndrome, and tumor lysis syndrome. (en)
http://linked.open...umeOfDistribution	The steady state volume of distribution is 6-10 L. (en)
http://linked.open...nk/proteinBinding	MMAE has a plasma protein binding range of 68-82%, and highly-protein bound drugs are not likely to displace it. (en)
http://linked.open...ynthesisReference	Francisco JA, Cerveny CG, Meyer DL, Mixan BJ, Klussman K, Chace DF, Rejniak SX, Gordon KA, DeBlanc R, Toki BE, Law CL, Doronina SO, Siegall CB, Senter PD, Wahl AF: cAC10-vcMMAE, an anti-CD30-monomethyl auristatin E conjugate with potent and selective antitumor activity. Blood. 2003 Aug 15;102(4):1458-65. Epub 2003 Apr 24 (en)
foaf:page	http://www.drugs.com/mtm/brentuximab-vedotin.html http://www.rxlist.com/adcetris-drug.htm
http://linked.open...Molecular-Formula	http://linked.opendata.cz/resource/drugbank/property/271B59A2-363D-11E5-9242-09173F13E4C5
http://linked.open.../Molecular-Weight	http://linked.opendata.cz/resource/drugbank/property/271B59A1-363D-11E5-9242-09173F13E4C5
http://linked.open...l/drug/hasATCCode	Brentuximab vedotin
http://linked.open...ugbank/absorption	Brentuximab vedotin is administered only as an intravenous infusion so absorption is 100%. (en)
http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	914088-09-8 (en)
http://linked.open...rugbank/clearance	MMAE is cleared by the liver but not quantitative studies have been performed. (en)

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