About: Tetraethylammonium     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

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http://linked.open...gbank/description
  • Tetraethylammonium is an experimental drug with no approved indication or marketed formulation. The only marketed drug containing tetraethylammonium was a combination drug called Fosglutamina B6, but this drug has now been discontinued. As an experimental agent, tetraethylammonium is used in its salt forms such as tetraethylammonium chloride and tetraethylammonium bromide. Its mechanism of action is still being investigated, but it is known that tetraethylammonium blocks autonomic ganglia, calcium- and voltage- activated potassium channels, and nicotinic acetylcholine receptors. Because of its inhibitory actions at the autonomic ganglia, tetraethylammonium was thought to be a potential therapeutic vasodilator but serious toxic effects were found. The most common use of tetraethylammonium presently is as a pharmacological research agent that blocks selective potassium channels. Structurally, tetraethylammonium is positively charged due to its central quaternary ammonium. (en)
http://linked.open...generalReferences
  • # The Merck Index. # Remington: The Science and Practice of Pharmacy. # GRAHAM AJ: Toxic effects in animals and man after tetraethylammonium bromide. Br Med J. 1950 Aug 5;2(4674):321-2. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/15434379 (en)
http://linked.open...gy/drugbank/group
  • experimental (en)
http://linked.open...ugbank/indication
  • Tetraethylammonium is an experimental drug with no approved indication. (en)
sameAs
Title
  • Tetraethylammonium (en)
adms:identifier
http://linked.open...mechanismOfAction
  • Tetraethylammonium's mechanism of action is still being investigated, but it is known that it blocks autonomic ganglia, calcium- and voltage- activated potassium channels, and nicotinic acetylcholine receptors. (en)
http://linked.open...outeOfElimination
  • Tetraethylammonium is eliminated by active renal tubular secretion by the cation transport system. (en)
http://linked.open.../drugbank/synonym
  • TEA (en)
http://linked.open...drugbank/toxicity
  • Studies in animals and humans have reported cases of serious muscle paralysis, which can lead to respiratory distress and death. (en)
http://linked.open.../drugbank/mixture
http://linked.open...ogy/drugbank/salt
  • (en)
http://linked.open...ugbank/IUPAC-Name
http://linked.open...gy/drugbank/InChI
http://linked.open...Molecular-Formula
http://linked.open.../Molecular-Weight
http://linked.open...noisotopic-Weight
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http://linked.open.../Water-Solubility
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http://linked.open...nd-Acceptor-Count
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http://linked.open...bank/Refractivity
http://linked.open...atable-Bond-Count
http://linked.open.../affectedOrganism
  • Humans and other mammals (en)
http://linked.open...casRegistryNumber
  • 66-40-0 (en)
http://linked.open...drugbank/category
  • (en)
http://linked.open...k/Bioavailability
http://linked.open...bank/Ghose-Filter
http://linked.open...nk/MDDR-Like-Rule
http://linked.open...ank/Melting-Point
http://linked.open...k/Number-of-Rings
http://linked.open...siological-Charge
http://linked.open...bank/Rule-of-Five
http://linked.open...tional-IUPAC-Name
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