About: Temocapril     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
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http://linked.open...gbank/description
  • Temocapril is a prodrug-type angiotensin-I converting enzyme (ACE) inhibitor not approved for use in the United States, but is approved in Japan and South Korea. Temocapril can also be used in hemodialysis patients without risk of serious accumulation. (en)
http://linked.open...generalReferences
  • # Tsuji A: Transporter-mediated Drug Interactions. Drug Metab Pharmacokinet. 2002;17(4):253-74. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/15618677 # Furuta S, Kiyosawa K, Higuchi M, Kasahara H, Saito H, Shioya H, Oguchi H: Pharmacokinetics of temocapril, an ACE inhibitor with preferential biliary excretion, in patients with impaired liver function. Eur J Clin Pharmacol. 1993;44(4):383-5. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/ 8513851 # Nakashima M, Yamamoto J, Shibata M, Uematsu T, Shinjo H, Akahori T, Shioya H, Sugiyama K, Kawahara Y: Pharmacokinetics of temocapril hydrochloride, a novel angiotensin converting enzyme inhibitor, in renal insufficiency. Eur J Clin Pharmacol. 1992;43(6):657-9. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/1493850 # Yasunari K, Maeda K, Nakamura M, Watanabe T, Yoshikawa J, Asada A: Pharmacological and clinical studies with temocapril, an angiotensin converting enzyme inhibitor that is excreted in the bile. Cardiovasc Drug Rev. 2004 Fall;22(3):189-98. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/15492767 # Dr Yutaka Koda, Hironobu Saito, Kunihiro Sasahara, Yoshihei Hirasawa, Clearance of Temocapril and Enalapril during Haemodialysis Treatment, Clinical Drug Investigation, April 1995, Volume 9, Issue 4, pp 232-238. (en)
http://linked.open...gy/drugbank/group
  • experimental (en)
  • investigational (en)
http://linked.open...drugbank/halfLife
  • 13.1 hours in patients with normal liver function. (en)
http://linked.open...ugbank/indication
  • Temocapril is an ACE inhibitor primarily indicated in the treatment of hypertension and congestive heart failure, diabetic nephropathy, and improvement of prognosis for coronary artery diseases (including acute myocardial infarction). (en)
sameAs
Title
  • Temocapril (en)
adms:identifier
http://linked.open...outeOfElimination
  • Temocapril is eliminated primarily through the liver and kidneys. (en)
http://linked.open.../drugbank/synonym
  • Temocaprilum (en)
http://linked.open...drugbank/toxicity
  • In rats, whether or male or female, the LD50 values of temocapril were higher than 5000 mg/kg. (en)
http://linked.open...nk/proteinBinding
  • 99.5%, including those with renal impairment. (en)
http://linked.open...ogy/drugbank/salt
  • (en)
foaf:page
http://linked.open...ugbank/IUPAC-Name
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http://linked.open...ugbank/absorption
  • Temocapril is rapidly absorbed in the gastrointestinal tract and converted into the diacid (active) metabolite, which inhibits ACE in plasma. (en)
http://linked.open.../affectedOrganism
  • Humans and other mammals (en)
http://linked.open...casRegistryNumber
  • 111902-57-9 (en)
http://linked.open...drugbank/category
  • (en)
http://linked.open...rugbank/clearance
  • 19.4% urinary recovery. (en)
http://linked.open...k/Bioavailability
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http://linked.open...strongest-acidic-
http://linked.open...-strongest-basic-
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