About: Dehydroascorbic Acid     Goto   Sponge   NotDistinct   Permalink

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  • Dehydroascorbic acid is made from the oxidation of ascorbic acid. This reaction is reversible, but dehydroascorbic acid can instead undergo irreversible hydrolysis to 2,3-diketogulonic acid. Dehydroascorbic acid as well as ascorbic acid are both termed Vitamin C, but the latter is the main form found in humans. In the body, both dehydroascorbic acid and ascorbic acid have similar biological activity as antivirals but dehydroascorbic acid also has neuroprotective effects. Currently dehydroascorbic acid is an experimental drug with no known approved indications. (en)
http://linked.open...generalReferences
  • # AHFS Drug Information. # Agus DB, Gambhir SS, Pardridge WM, Spielholz C, Baselga J, Vera JC, Golde DW: Vitamin C crosses the blood-brain barrier in the oxidized form through the glucose transporters. J Clin Invest. 1997 Dec 1;100(11):2842-8. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/9389750 # Huang J, Agus DB, Winfree CJ, Kiss S, Mack WJ, McTaggart RA, Choudhri TF, Kim LJ, Mocco J, Pinsky DJ, Fox WD, Israel RJ, Boyd TA, Golde DW, Connolly ES Jr: Dehydroascorbic acid, a blood-brain barrier transportable form of vitamin C, mediates potent cerebroprotection in experimental stroke. Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11720-4. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/11573006 # Furuya A, Uozaki M, Yamasaki H, Arakawa T, Arita M, Koyama AH: Antiviral effects of ascorbic and dehydroascorbic acids in vitro. Int J Mol Med. 2008 Oct;22(4):541-5. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/18813862 (en)
http://linked.open...gy/drugbank/group
  • experimental (en)
http://linked.open...ugbank/indication
  • There is no approved indication for dehydroascorbic acid, but it has potential therapeutic use in patients with certain viruses and ischemic stroke. (en)
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Title
  • Dehydroascorbic Acid (en)
adms:identifier
http://linked.open...mechanismOfAction
  • Even though dehydroascorbic acid and ascorbic acid have similar effects, their mechanism of action seems to be different. The exact mechanism of action is still being investigated, but some have been elucidated. Concerning dehydroascorbic acid's antiviral effect against herpes simplex virus type 1, it is suggested that dehydroascorbic acid acts after replication of viral DNA and prevents the assembly of progeny virus particles. (en)
http://linked.open.../drugbank/synonym
  • Dehydroascorbate (en)
  • L-Dehydroascorbate (en)
  • L-dehydroascorbic acid (en)
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  • Humans and other mammals (en)
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  • 490-83-5 (en)
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  • (en)
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