About: Plicamycin

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	Plicamycin is an antineoplastic antibiotic produced by Streptomyces plicatus. It has been used in the treatment of testicular cancer, Paget's disease of bone, and, rarely, the management of hypercalcemia. The manufacturer discontinued plicamycin in 2000. (en)
http://linked.open...generalReferences	# Wohlert SE, Kunzel E, Machinek R, Mendez C, Salas JA, Rohr J: The structure of mithramycin reinvestigated. J Nat Prod. 1999 Jan;62(1):119-21. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/9917296 (en)
http://linked.open...gy/drugbank/group	approved (en) withdrawn (en)
http://linked.open...ugbank/indication	For the treatment of testicular cancer, as well as hypercalcemia and hypercalciuria associated with a variety of advanced forms of cancer. (en)
sameAs	Plicamycin
Title	Plicamycin (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB06810/identifier/chebi/31856 http://linked.opendata.cz/resource/drugbank/drug/DB06810/identifier/drugbank/DB06810 http://linked.opendata.cz/resource/drugbank/drug/DB06810/identifier/kegg-compound/C12389 http://linked.opendata.cz/resource/drugbank/drug/DB06810/identifier/kegg-drug/D00468 http://linked.opendata.cz/resource/drugbank/drug/DB06810/identifier/pharmgkb/PA165958411 http://linked.opendata.cz/resource/drugbank/drug/DB06810/identifier/wikipedia/Plicamycin
http://linked.open...mechanismOfAction	Plicamycin is presumed to inhibit cellular and enzymic RNA synthesis by forming a complex with DNA. Plicamycin may also lower calcium serum levels by inhibiting the effect of parathyroid hormone upon osteoclasts or by blocking the hypercalcemic action of pharmacologic doses of vitamin D. (en)
http://linked.open...outeOfElimination	Radioautography studies with 3H-labeled plicamycin in mice show that the greatest concentrations of the isotope are in the Kupffer cells of the liver and cells of the renal tubules. Plicamycin is rapidly cleared from the blood within the first 2 hours and excretion is also rapid. 67% percent of measured excretion occurs within 4 hours, 75% within 8 hours, and 90% is recovered in the first 24 hours after injection. (en)
http://linked.open.../drugbank/synonym	Plicamycin (en) Mithracin (en) Mithramycin (en) Aureolic acid (en) Mithramycine (en) Mithramycinum (en) Plicamycine (en) Plicamycinum (en)
http://linked.open...drugbank/toxicity	The most important form of toxicity associated with the use of plicamycin consists of a dose-related bleeding syndrome which usually begins with an episode of epistaxis. Plicamycin crosses the blood-brain barrier; the concentration found in brain tissue is low but it persists longer than in other tissues. (en)
http://linked.open...nk/proteinBinding	There is no evidence of protein binding, nor is there any evidence of metabolism of the carbohydrate moiety of the drug to carbon dioxide and water with loss through respiration. (en)
http://linked.open...ynthesisReference	Jurgen Rohr, Lily Remsing, Mohammad Nur-e-Alam, Jose Salas, Carmen Mendez, Alfredo Brana, Ana Gonzalez, "Derivatives of mithramycin and methods of making and uses thereof." U.S. Patent US20050192432, issued September 01, 2005. (en)
foaf:page	http://www.drugs.com/mtm/plicamycin.html http://www.rxlist.com/mithracin-drug.htm
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http://linked.open...casRegistryNumber	18378-89-7 (en)
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