About: Nepafenac

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	Nepafenac is a non-steroidal anti-inflammatory prodrug (NSAID) usually sold as a prescription eye drop. It is used to treat pain and inflammation associated with cataract surgery. (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B54BA-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B54BB-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B54BC-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B54BD-363D-11E5-9242-09173F13E4C5
http://linked.open...generalReferences	# Gamache DA, Graff G, Brady MT, Spellman JM, Yanni JM: Nepafenac, a unique nonsteroidal prodrug with potential utility in the treatment of trauma-induced ocular inflammation: I. Assessment of anti-inflammatory efficacy. Inflammation. 2000 Aug;24(4):357-70. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10850857 # Ke TL, Graff G, Spellman JM, Yanni JM: Nepafenac, a unique nonsteroidal prodrug with potential utility in the treatment of trauma-induced ocular inflammation: II. In vitro bioactivation and permeation of external ocular barriers. Inflammation. 2000 Aug;24(4):371-84. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10850858 # Lane SS, Modi SS, Lehmann RP, Holland EJ: Nepafenac ophthalmic suspension 0.1% for the prevention and treatment of ocular inflammation associated with cataract surgery. J Cataract Refract Surg. 2007 Jan;33(1):53-8. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17189793 # Walters T, Raizman M, Ernest P, Gayton J, Lehmann R: In vivo pharmacokinetics and in vitro pharmacodynamics of nepafenac, amfenac, ketorolac, and bromfenac. J Cataract Refract Surg. 2007 Sep;33(9):1539-45. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17720067 # Bucci FA Jr, Waterbury LD: Re: Pharmacokinetics and pharmacodynamics of nepafenac, amfenac, ketorolac, and bromfenac. J Cataract Refract Surg. 2008 Aug;34(8):1226; author reply 1226-7. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/18655957 # Summary Basis of Decision (SBD): NEVANAC. "Health Canada":http://www.hc-sc.gc.ca/dhp-mps/prodpharma/sbd-smd/phase1-decision/drug-med/sbd_smd_2008_nevanac_114004-eng.php (en)
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...ugbank/indication	For the treatment of pain and inflammation associated with cataract surgery. (en)
sameAs	Nepafenac
Title	Nepafenac (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB06802/identifier/chemspider/133160 http://linked.opendata.cz/resource/drugbank/drug/DB06802/identifier/drugbank/DB06802 http://linked.opendata.cz/resource/drugbank/drug/DB06802/identifier/kegg-drug/D05143 http://linked.opendata.cz/resource/drugbank/drug/DB06802/identifier/national-drug-code-directory/0065-0002-01 http://linked.opendata.cz/resource/drugbank/drug/DB06802/identifier/pubchem-compound/151075 http://linked.opendata.cz/resource/drugbank/drug/DB06802/identifier/pubchem-substance/99443294 http://linked.opendata.cz/resource/drugbank/drug/DB06802/identifier/pharmgkb/PA165958407 http://linked.opendata.cz/resource/drugbank/drug/DB06802/identifier/wikipedia/Nepafenac
http://linked.open...mechanismOfAction	Nepafenac is a prodrug. After penetrating the cornea, nepafenac undergoes rapid bioactivation to amfenac, which is a potent NSAID that uniformly inhibits the COX1 and COX2 activity. (en)
http://linked.open...outeOfElimination	After oral administration of 14C-nepafenac to healthy volunteers, urinary excretion was found to be the major route of radioactivity elimination, accounting for approximately 85% of the dose, while fecal excretion represented approximately 6% of the dose. Nepafenac (prodrug) and amfenac (active compound) were not quantifiable in the urine. (en)
http://linked.open.../drugbank/synonym	Nevanac (en) Amfenac amide (en) 2-amino-3-Benzoylbenzeneacetamide (en) AHR 9434 (en) AHR-9434 (en) AL 6515 (en) AL-6515 (en) Nepafenaco (en) Nepafenacum (en)
http://linked.open...drugbank/toxicity	Ocularly applied non-steroidal anti-inflammatory drugs may cause increased bleeding of ocular tissues (including hyphemas) in conjunction with ocular surgery. (en)
http://linked.open...nk/proteinBinding	Amfenac has high affinity toward serum albumin proteins. In vitro, the percent bound to human albumin and human serum was 95.4% and 99.1% respectively. (en)
foaf:page	http://www.drugs.com/ppa/nepafenac.html http://www.rxlist.com/nevanac-drug.htm
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http://linked.open...l/drug/hasATCCode	Nepafenac
http://linked.open...nd-Acceptor-Count	http://linked.opendata.cz/resource/drugbank/property/271B54CE-363D-11E5-9242-09173F13E4C5
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http://linked.open...ugbank/absorption	Nepafenac rapidly cross the cornea (6 times faster than diclofenac in vitro). (en)
http://linked.open...casRegistryNumber	78281-72-8 (en)
http://linked.open...drugbank/category	(en)
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