| Attributes | Values |
|---|
| rdf:type
| |
| http://linked.open...gbank/description
| - Mafenide is a sulfonamide-type medication used to treat severe burns. It acts by reducing the bacterial population present in the burn tissue and promotes healing of deep burns. (en)
|
| http://linked.open...y/drugbank/dosage
| |
| http://linked.open...generalReferences
| - # Maghsoudi H, Salehi F, Khosrowshahi MK, Baghaei M, Nasirzadeh M, Shams R: Comparison between topical honey and mafenide acetate in treatment of burn wounds. Ann Burns Fire Disasters. 2011 Sep 30;24(3):132-7. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/22396671 (en)
|
| http://linked.open...gy/drugbank/group
| |
| http://linked.open...ugbank/indication
| - Mafenide is indicated in the treatment of severe burns. (en)
|
| sameAs
| |
| Title
| |
| adms:identifier
| |
| http://linked.open...mechanismOfAction
| - The precise mechanism of mafenide is unknown. However, mafenide reduces the bacterial population in the avascular burn tissue and promotes spontaneous heeling of deep burns. (en)
|
| http://linked.open...outeOfElimination
| - Renal—Metabolite rapidly excreted in urine in high concentrations; however, the parent compound has not been detected in urine. (en)
|
| http://linked.open.../drugbank/synonym
| - Bensulfamide (en)
- 4-(aminomethyl)benzenesulfonamide (en)
- 4-Homosufanilamide (en)
- Maphenidum (en)
|
| http://linked.open...drugbank/toxicity
| - Since mafenide is metabolized to a carbonic anhydrase inhibitor, metabolic acidosis could occur. Mafenide is contraindicated in persons with renal impairment or sulfonamide hypersensitivity. (en)
|
| http://linked.open.../drugbank/mixture
| |
| http://linked.open...ogy/drugbank/salt
| |
| http://linked.open...ynthesisReference
| - U.S. Patent 2,288,531. (en)
|
| foaf:page
| |
| http://linked.open...ugbank/IUPAC-Name
| |
| http://linked.open...gy/drugbank/InChI
| |
| http://linked.open...Molecular-Formula
| |
| http://linked.open.../Molecular-Weight
| |
| http://linked.open...noisotopic-Weight
| |
| http://linked.open...y/drugbank/SMILES
| |
| http://linked.open.../Water-Solubility
| |
| http://linked.open...ogy/drugbank/logP
| |
| http://linked.open...ogy/drugbank/logS
| |
| http://linked.open...l/drug/hasATCCode
| |
| http://linked.open...nd-Acceptor-Count
| |
| http://linked.open...-Bond-Donor-Count
| |
| http://linked.open...drugbank/InChIKey
| |
| http://linked.open...urface-Area--PSA-
| |
| http://linked.open...nk/Polarizability
| |
| http://linked.open...bank/Refractivity
| |
| http://linked.open...atable-Bond-Count
| |
| http://linked.open...ugbank/absorption
| - Mafenide is absorbed through devascularized areas into the systemic circulation following topical administration. (en)
|
| http://linked.open.../affectedOrganism
| - Bacteria (en)
- Gram negative and gram positive bacteria (en)
- Pseudomonas aeruginosa (en)
|
| http://linked.open...casRegistryNumber
| |
| http://linked.open...k/Bioavailability
| |
| http://linked.open...bank/Ghose-Filter
| |
| http://linked.open...nk/MDDR-Like-Rule
| |
| http://linked.open...ank/Melting-Point
| |
| http://linked.open...k/Number-of-Rings
| |
| http://linked.open...siological-Charge
| |
| http://linked.open...bank/Rule-of-Five
| |
| http://linked.open...tional-IUPAC-Name
| |
| http://linked.open...strongest-acidic-
| |
| http://linked.open...-strongest-basic-
| |
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