About: Velaglucerase alfa

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	Velaglucerase alfa is a gene-activated human recombinant glucocerebrosidase used for the treatment of Type 1 Gaucher disease, caused by a deficiency of the lysosomal enzyme glucocerebrosidase. Additionally, Velaglucerase alfa has also been investigated for use in Type 3 Gaucher disease. (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B5150-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5151-363D-11E5-9242-09173F13E4C5
http://linked.open...generalReferences	# Pastores GM: Velaglucerase alfa, a human recombinant glucocerebrosidase enzyme replacement therapy for type 1 Gaucher disease. Curr Opin Investig Drugs. 2010 Apr;11(4):472-8. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/20336596 # Vairo F, Netto C, Dorneles A, Mittelstadt S, Wilke M, Doneda D, Michelin K, Ribeiro CB, Quevedo A, Vieira T, Nalin T, Lueska S, Schwartz IV: Enzyme Replacement Therapy in a Patient with Gaucher Disease Type III: A Paradigmatic Case Showing Severe Adverse Reactions Started a Long Time After the Beginning of Treatment. JIMD Rep. 2013 Feb 21. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/23430813 (en)
http://linked.open...gy/drugbank/group	approved (en) investigational (en)
http://linked.open...drugbank/halfLife	11-12 minutes. (en)
http://linked.open...ugbank/indication	Velaglucerase alfa is a hydrolytic lysosomal glucocerebroside-specific enzyme indicated for long-term enzyme replacement therapy for pediatric and adult patients with type 1 Gaucher disease. (en)
sameAs	Velaglucerase alfa
Title	Velaglucerase alfa (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB06720/identifier/drugbank/DB06720 http://linked.opendata.cz/resource/drugbank/drug/DB06720/identifier/kegg-drug/D09029 http://linked.opendata.cz/resource/drugbank/drug/DB06720/identifier/national-drug-code-directory/54092-701-04 http://linked.opendata.cz/resource/drugbank/drug/DB06720/identifier/uniprotkb/P04062 http://linked.opendata.cz/resource/drugbank/drug/DB06720/identifier/wikipedia/Velaglucerase_alfa
http://linked.open...mechanismOfAction	Velaglucerase alfa catalyzes the hydrolysis of glucocerebroside, reducing the amount of accumulated glucocerebroside. (en)
http://linked.open...y/drugbank/patent	http://linked.opendata.cz/resource/drugbank/patent/7138262
http://linked.open.../drugbank/synonym	Imiglucerase (en) VPRIV (en)
http://linked.open...umeOfDistribution	The mean volume of distribution at steady state ranges from 82 to 108 mL/kg (8.2% to 10.8% of body weight). (en)
foaf:page	http://www.drugs.com/vpriv.html3 http://www.pdrhealth.com/info/v1us/vpriv http://www.rxlist.com/vpriv-drug.htm
http://linked.open...Molecular-Formula	http://linked.opendata.cz/resource/drugbank/property/271B5153-363D-11E5-9242-09173F13E4C5
http://linked.open.../Molecular-Weight	http://linked.opendata.cz/resource/drugbank/property/271B5152-363D-11E5-9242-09173F13E4C5
http://linked.open...l/drug/hasATCCode	Velaglucerase alfa
http://linked.open...casRegistryNumber	884604-91-5 (en)
http://linked.open...drugbank/category	(en)
http://linked.open...rugbank/clearance	Mean clearance ranges from 6.72 to 7.56 mL/min/kg. (en)

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