About: Pertuzumab

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About: Pertuzumab Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	Pertuzumab is a recombinant humanized monoclonal antibody that targets the extracellular dimerization domain (Subdomain II) of the human epidermal growth factor receptor 2 protein (HER2). It consists of two heavy chains and two lights chains that have 448 and 214 residues respectively. FDA approved June 8, 2012. (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B4C5D-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4C5E-363D-11E5-9242-09173F13E4C5
http://linked.open...generalReferences	# Protein sequence "Link":www.freepatentsonline.com/20110117097.pdf # FDA label (en)
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...drugbank/halfLife	18 days (en)
http://linked.open...ugbank/indication	Pertuzumab is indicated for use in combination with trastuzumab and docetaxel for the treatment of patients with HER2-positive metastatic breast cancer who have not received prior anti-HER2 therapy or chemotherapy for metastatic disease. (en)
sameAs	Pertuzumab
Title	Pertuzumab (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB06366/identifier/drugbank/DB06366 http://linked.opendata.cz/resource/drugbank/drug/DB06366/identifier/kegg-drug/D05446 http://linked.opendata.cz/resource/drugbank/drug/DB06366/identifier/national-drug-code-directory/50242-145-01 http://linked.opendata.cz/resource/drugbank/drug/DB06366/identifier/wikipedia/Pertuzumab
http://linked.open...mechanismOfAction	Pertuzumab is a humanized monoclonal antibody designed to bind to the HER2 receptor and inhibit the ability of HER2 to interact with other HER family members (HER1, HER2, HER3, and HER4) on the surface of cancer cells. The HER signaling pathway plays a role in the formation and growth of numerous cancers, and previous clinical trials of pertuzumab in a single agent setting had suggested clinical activity - including stable disease - in heavily pretreated patients with advanced ovarian and breast cancers. (en)
http://linked.open...y/drugbank/patent	http://linked.opendata.cz/resource/drugbank/patent/2376596 http://linked.opendata.cz/resource/drugbank/patent/2579861
http://linked.open.../drugbank/synonym	2C4 Antibody (en) MOAB 2C4 (en) Monoclonal Antibody 2C4 (en) Omnitarg (en) rhuMAb-2C4 (en)
http://linked.open...drugbank/toxicity	The most common adverse reactions (> 30%) with PERJETA in combination with trastuzumab and docetaxel were diarrhea, alopecia, neutropenia, nausea, fatigue, rash, and peripheral neuropathy. (en)
http://linked.open...umeOfDistribution	5.12 L (en)
http://linked.open.../drug/hasAHFSCode	http://linked.opendata.cz/resource/AHFS/10-00
foaf:page	http://www.drugs.com/perjeta.html file:/data/uv/backend/working/exec_7200/storage/dpu_9769/1/www.rxlist.com/perjeta-drug.htm
http://linked.open.../Molecular-Weight	http://linked.opendata.cz/resource/drugbank/property/271B4C5F-363D-11E5-9242-09173F13E4C5
http://linked.open...l/drug/hasATCCode	Pertuzumab
http://linked.open...ugbank/absorption	When an initial dose of 840 mg followed by a maintenance dose of 420 mg every three weeks thereafter is administered, steady-state concentrations were achieved on the first maintenance dose. (en)
http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	380610-27-5 (en)
http://linked.open...drugbank/category	(en)
http://linked.open...rugbank/clearance	0.24 L/day (en)

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