About: Sertindole

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Sertindole Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	Sertindole, a neuroleptic, is one of the newer antipsychotic medications available. Serdolect is developed by the Danish pharmaceutical company H. Lundbeck. Like the other atypical antipsychotics, it has activity at dopamine and serotonin receptors in the brain. It is used in the treatment of schizophrenia. It is classified chemically as a phenylindole derivative. It was first marketed in 1996 in several European countries before being withdrawn two years later because of numerous cardiac adverse effects. It has once again been approved and should soon be available on the French and Australian market. (en)
http://linked.open...generalReferences	# Kane JM, Tamminga CA: Sertindole (Serdolect): preclinical and clinical findings of a new atypical antipsychotic. Expert Opin Investig Drugs. 1997 Nov;6(11):1729-41. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/15989577 # Lewis R, Bagnall AM, Leitner M: Sertindole for schizophrenia. Cochrane Database Syst Rev. 2005 Jul 20;(3):CD001715. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/16034864 # Perquin LN: Treatment with the new antipsychotic sertindole for late-occurring undesirable movement effects. Int Clin Psychopharmacol. 2005 Nov;20(6):335-8. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/16192844 # Murdoch D, Keating GM: Sertindole : a review of its use in schizophrenia. CNS Drugs. 2006;20(3):233-55. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/16529528 # Sertindole: new drug. Another "atypical" neuroleptic; QT prolongation. Prescrire Int. 2007 Apr;16(88):59-62. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17458045 # Lindstrom E, Levander S: Sertindole: efficacy and safety in schizophrenia. Expert Opin Pharmacother. 2006 Sep;7(13):1825-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/16925508 # Hertel P: Comparing sertindole to other new generation antipsychotics on preferential dopamine output in limbic versus striatal projection regions: mechanism of action. Synapse. 2006 Dec 1;60(7):543-52. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/16952163 (en)
http://linked.open...gy/drugbank/group	approved (en) withdrawn (en)
http://linked.open...drugbank/halfLife	3 days (en)
http://linked.open...ugbank/indication	Used in the treatment of schizophrenia. (en)
sameAs	Sertindole
Title	Sertindole (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB06144/identifier/chebi/9122 http://linked.opendata.cz/resource/drugbank/drug/DB06144/identifier/chemspider/54229 http://linked.opendata.cz/resource/drugbank/drug/DB06144/identifier/drugbank/DB06144 http://linked.opendata.cz/resource/drugbank/drug/DB06144/identifier/guide-to-pharmacology/98 http://linked.opendata.cz/resource/drugbank/drug/DB06144/identifier/iuphar/98 http://linked.opendata.cz/resource/drugbank/drug/DB06144/identifier/kegg-compound/C07567 http://linked.opendata.cz/resource/drugbank/drug/DB06144/identifier/kegg-drug/D00561 http://linked.opendata.cz/resource/drugbank/drug/DB06144/identifier/pubchem-compound/60149 http://linked.opendata.cz/resource/drugbank/drug/DB06144/identifier/pubchem-substance/46504717 http://linked.opendata.cz/resource/drugbank/drug/DB06144/identifier/pharmgkb/PA164784002 http://linked.opendata.cz/resource/drugbank/drug/DB06144/identifier/wikipedia/Sertindole
http://linked.open...mechanismOfAction	Sertindole is an antipsychotic drug with affinity for dopamine D2, serotonin 5-HT2A and 5-HT2C, and alpha1-adrenoreceptors. Preclinical studies suggest that sertindole acts preferentially on limbic and cortical dopaminergic neurons and clinical trials have confirmed that sertindole is effective at a low dopamine D2 occupancy level. (en)
http://linked.open.../drugbank/synonym	Sertindole (en) Serdolect (en) 1-[2-[4-[5-chloro-1-(4-Fluorophenyl)-indol-3-yl]-1-piperidyl]ethyl]imidazolidin-2-one (en) SerLect (en) Sertindol (en) Sertindolum (en)
http://linked.open...ugbank/IUPAC-Name	http://linked.opendata.cz/resource/drugbank/property/271B48CB-363D-11E5-9242-09173F13E4C5
http://linked.open...gy/drugbank/InChI	http://linked.opendata.cz/resource/drugbank/property/271B48D1-363D-11E5-9242-09173F13E4C5
http://linked.open...Molecular-Formula	http://linked.opendata.cz/resource/drugbank/property/271B48D0-363D-11E5-9242-09173F13E4C5
http://linked.open.../Molecular-Weight	http://linked.opendata.cz/resource/drugbank/property/271B48CD-363D-11E5-9242-09173F13E4C5
http://linked.open...noisotopic-Weight	http://linked.opendata.cz/resource/drugbank/property/271B48CE-363D-11E5-9242-09173F13E4C5
http://linked.open...y/drugbank/SMILES	http://linked.opendata.cz/resource/drugbank/property/271B48CF-363D-11E5-9242-09173F13E4C5
http://linked.open.../Water-Solubility	http://linked.opendata.cz/resource/drugbank/property/271B48C9-363D-11E5-9242-09173F13E4C5
http://linked.open...ogy/drugbank/logP	http://linked.opendata.cz/resource/drugbank/property/271B48C7-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/property/271B48CA-363D-11E5-9242-09173F13E4C5
http://linked.open...ogy/drugbank/logS	http://linked.opendata.cz/resource/drugbank/property/271B48C8-363D-11E5-9242-09173F13E4C5
http://linked.open...l/drug/hasATCCode	Sertindole
http://linked.open...nd-Acceptor-Count	http://linked.opendata.cz/resource/drugbank/property/271B48D7-363D-11E5-9242-09173F13E4C5
http://linked.open...-Bond-Donor-Count	http://linked.opendata.cz/resource/drugbank/property/271B48D8-363D-11E5-9242-09173F13E4C5
http://linked.open...drugbank/InChIKey	http://linked.opendata.cz/resource/drugbank/property/271B48D2-363D-11E5-9242-09173F13E4C5
http://linked.open...urface-Area--PSA-	http://linked.opendata.cz/resource/drugbank/property/271B48D3-363D-11E5-9242-09173F13E4C5
http://linked.open...nk/Polarizability	http://linked.opendata.cz/resource/drugbank/property/271B48D5-363D-11E5-9242-09173F13E4C5
http://linked.open...bank/Refractivity	http://linked.opendata.cz/resource/drugbank/property/271B48D4-363D-11E5-9242-09173F13E4C5
http://linked.open...atable-Bond-Count	http://linked.opendata.cz/resource/drugbank/property/271B48D6-363D-11E5-9242-09173F13E4C5
http://linked.open...ugbank/absorption	Orally available. (en)
http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	106516-24-9 (en)
http://linked.open...drugbank/category	(en)
http://linked.open...k/Bioavailability	http://linked.opendata.cz/resource/drugbank/property/271B48DD-363D-11E5-9242-09173F13E4C5
http://linked.open...bank/Ghose-Filter	http://linked.opendata.cz/resource/drugbank/property/271B48DF-363D-11E5-9242-09173F13E4C5
http://linked.open...nk/MDDR-Like-Rule	http://linked.opendata.cz/resource/drugbank/property/271B48E0-363D-11E5-9242-09173F13E4C5
http://linked.open...k/Number-of-Rings	http://linked.opendata.cz/resource/drugbank/property/271B48DC-363D-11E5-9242-09173F13E4C5
http://linked.open...siological-Charge	http://linked.opendata.cz/resource/drugbank/property/271B48DB-363D-11E5-9242-09173F13E4C5
http://linked.open...bank/Rule-of-Five	http://linked.opendata.cz/resource/drugbank/property/271B48DE-363D-11E5-9242-09173F13E4C5
http://linked.open...tional-IUPAC-Name	http://linked.opendata.cz/resource/drugbank/property/271B48CC-363D-11E5-9242-09173F13E4C5
http://linked.open...strongest-acidic-	http://linked.opendata.cz/resource/drugbank/property/271B48D9-363D-11E5-9242-09173F13E4C5
http://linked.open...-strongest-basic-	http://linked.opendata.cz/resource/drugbank/property/271B48DA-363D-11E5-9242-09173F13E4C5

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 39 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software