About: substance P

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	Homspera is a generic name used by the Company to describe the synthetic peptide Sar9, Met (O2)11-Substance P. Sar9, Met (O2)11-Substance P is an analog of the naturally occurring human neuropeptide Substance P, which can be found throughout the body, including in the airways of humans and many other species. All of the Company's research and development efforts are in early, pre-clinical stages and Homspera, also known as Viprovex and Radilex, has only undergone exploratory studies to evaluate its biological activity in small animals. (en)
http://linked.open...generalReferences	# Grimsholm O, Rantapaa-Dahlqvist S, Dalen T, Forsgren S: Observations favouring the occurrence of local production and marked effects of bombesin/gastrin-releasing peptide in the synovial tissue of the human knee joint - Comparisons with substance P and the NK-1 receptor. Neuropeptides. 2008 Apr;42(2):133-45. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/18289674 # Rothstein RD, Johnson E, Ouyang A: Substance P: mechanism of action and receptor distribution at the feline ileocecal sphincter region. Am J Physiol. 1989 Sep;257(3 Pt 1):G447-53. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/2476938 # Sequence Information "Link":http://www.abcam.com/Substance-P-protein-ab9608.html (en)
http://linked.open...gy/drugbank/group	investigational (en)
http://linked.open...ugbank/indication	Investigated for use/treatment in acute respiratory distress syndrome (ARDS) and viral infection. (en)
sameAs	substance P
Title	substance P (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB05875/identifier/drugbank/DB05875 http://linked.opendata.cz/resource/drugbank/drug/DB05875/identifier/pubchem-compound/36511 http://linked.opendata.cz/resource/drugbank/drug/DB05875/identifier/wikipedia/Substance_P
http://linked.open...mechanismOfAction	The endogenous receptor for Substance P is neurokinin 1 receptor (NK1-receptor, NK1R). It belongs to the tachykinin receptor sub-family of GPCRs. Substance P has been shown to stimulate cellular growth in cell culture [2], and it was shown that Substance P could promote wound healing of non-healing ulcers in humans. [3] It has also been shown to reverse diabetes in mice. (en)
http://linked.open...Molecular-Formula	http://linked.opendata.cz/resource/drugbank/property/271B4861-363D-11E5-9242-09173F13E4C5
http://linked.open.../Molecular-Weight	http://linked.opendata.cz/resource/drugbank/property/271B4860-363D-11E5-9242-09173F13E4C5

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