About: Rivanicline

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	Rivanicline (TC-2403, RJR-2403, (E)-metanicotine) is a drug which acts as a partial agonist at neural nicotinic acetylcholine receptors. It is subtype-selective, binding primarily to the α4β2 subtype. It has nootropic effects and was originally developed as a potential treatment for Alzheimer's disease, but a second action that was subsequently found was that it inhibits the production of Interleukin-8 and thus produces an antiinflammatory effect, and so it has also been developed as a potential treatment for ulcerative colitis. Rivanicline also has stimulant and analgesic actions which are thought to be mediated through stimulation of noradrenaline release, and so it could potentially also have other applications. (en)
http://linked.open...generalReferences	# Spoettl T, Paetzel C, Herfarth H, Bencherif M, Schoelmerich J, Greinwald R, Gatto GJ, Rogler G: (E)-metanicotine hemigalactarate (TC-2403-12) inhibits IL-8 production in cells of the inflamed mucosa. Int J Colorectal Dis. 2007 Mar;22(3):303-12. Epub 2006 May 20. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/16715250 # Jang J, Sin KS, Park H: Synthesis of (+/-)-methyl-(1-aryl-4-pyridin-3-yl-but-3-enyl)-amines. Arch Pharm Res. 2001 Dec;24(6):503-7. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/11794523 # Sapronov NS, Fedotova YO, Kuznetsova NN: Antiamnestic effect of alpha7-nicotinic receptor agonist RJR-2403 in middle-aged ovariectomized rats with Alzheimer type dementia. Bull Exp Biol Med. 2006 Dec;142(6):700-2. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17603674 # Li X, Eisenach JC: Nicotinic acetylcholine receptor regulation of spinal norepinephrine release. Anesthesiology. 2002 Jun;96(6):1450-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/12170059 (en)
http://linked.open...gy/drugbank/group	investigational (en)
http://linked.open...ugbank/indication	Investigated for use/treatment in ulcerative colitis. (en)
sameAs	Rivanicline
Title	Rivanicline (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB05855/identifier/bindingdb/50061561 http://linked.opendata.cz/resource/drugbank/drug/DB05855/identifier/chemspider/4470511 http://linked.opendata.cz/resource/drugbank/drug/DB05855/identifier/drugbank/DB05855 http://linked.opendata.cz/resource/drugbank/drug/DB05855/identifier/pubchem-compound/5310967 http://linked.opendata.cz/resource/drugbank/drug/DB05855/identifier/wikipedia/Rivanicline
http://linked.open...mechanismOfAction	Rivanicline is a (E)-metanicotine hemigalactarate. It effectively inhibits TNF- and LPS-induced IL-8 production in different cell types. (en)
http://linked.open.../drugbank/synonym	(E)-N-Methyl-4-(3-pyridinyl)-3-butene-1-amine (en)
http://linked.open...ugbank/IUPAC-Name	http://linked.opendata.cz/resource/drugbank/property/271B47C9-363D-11E5-9242-09173F13E4C5
http://linked.open...gy/drugbank/InChI	http://linked.opendata.cz/resource/drugbank/property/271B47CF-363D-11E5-9242-09173F13E4C5
http://linked.open...Molecular-Formula	http://linked.opendata.cz/resource/drugbank/property/271B47CE-363D-11E5-9242-09173F13E4C5
http://linked.open.../Molecular-Weight	http://linked.opendata.cz/resource/drugbank/property/271B47CB-363D-11E5-9242-09173F13E4C5
http://linked.open...noisotopic-Weight	http://linked.opendata.cz/resource/drugbank/property/271B47CC-363D-11E5-9242-09173F13E4C5
http://linked.open...y/drugbank/SMILES	http://linked.opendata.cz/resource/drugbank/property/271B47CD-363D-11E5-9242-09173F13E4C5
http://linked.open.../Water-Solubility	http://linked.opendata.cz/resource/drugbank/property/271B47C7-363D-11E5-9242-09173F13E4C5
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http://linked.open...ogy/drugbank/logS	http://linked.opendata.cz/resource/drugbank/property/271B47C6-363D-11E5-9242-09173F13E4C5
http://linked.open...nd-Acceptor-Count	http://linked.opendata.cz/resource/drugbank/property/271B47D5-363D-11E5-9242-09173F13E4C5
http://linked.open...-Bond-Donor-Count	http://linked.opendata.cz/resource/drugbank/property/271B47D6-363D-11E5-9242-09173F13E4C5
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http://linked.open...urface-Area--PSA-	http://linked.opendata.cz/resource/drugbank/property/271B47D1-363D-11E5-9242-09173F13E4C5
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http://linked.open...atable-Bond-Count	http://linked.opendata.cz/resource/drugbank/property/271B47D4-363D-11E5-9242-09173F13E4C5
http://linked.open...casRegistryNumber	538-79-4 (en)
http://linked.open...k/Bioavailability	http://linked.opendata.cz/resource/drugbank/property/271B47DA-363D-11E5-9242-09173F13E4C5
http://linked.open...bank/Ghose-Filter	http://linked.opendata.cz/resource/drugbank/property/271B47DC-363D-11E5-9242-09173F13E4C5
http://linked.open...nk/MDDR-Like-Rule	http://linked.opendata.cz/resource/drugbank/property/271B47DD-363D-11E5-9242-09173F13E4C5
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http://linked.open...siological-Charge	http://linked.opendata.cz/resource/drugbank/property/271B47D8-363D-11E5-9242-09173F13E4C5
http://linked.open...bank/Rule-of-Five	http://linked.opendata.cz/resource/drugbank/property/271B47DB-363D-11E5-9242-09173F13E4C5
http://linked.open...tional-IUPAC-Name	http://linked.opendata.cz/resource/drugbank/property/271B47CA-363D-11E5-9242-09173F13E4C5
http://linked.open...-strongest-basic-	http://linked.opendata.cz/resource/drugbank/property/271B47D7-363D-11E5-9242-09173F13E4C5

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