About: 99mTc-ciprofloxacin     Goto   Sponge   NotDistinct   Permalink

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http://linked.open...gbank/description
  • 99mTc-Ciprofloxacin is a new formulation of ciprofloxacin (INFECTON), being investigated as a radioimaging agent for the potential diagnosis of infection, including fever of unknown origin, osteomyelitis, wound infection, abdominal abscess, pneumonia, appendicitis and tuberculosis. INFECTON combines the widely used antibiotic, ciprofloxacin, with Technetium ((99m)Tc), the most commonly used radioisotope in nuclear medical imaging There is currently controversy around the drug's ability to discriminate between sterile inflammation and bacterial versus nonbacterial infections. (en)
http://linked.open...generalReferences
  • # Choe YM, Choe W, Lee KY, Ahn SI, Kim K, Cho YU, Choi SK, Hur YS, Kim SJ, Hong KC, Shin SH, Kim KR, Woo ZH: Tc-99m ciprofloxacin imaging in acute cholecystitis. World J Gastroenterol. 2007 Jun 21;13(23):3249-52. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17589906 # Markou P, Spyridonidis T: [The role of 99mTc-ciprofloxacin scan in infection imaging] Hell J Nucl Med. 2005 May-Aug;8(2):74-80. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/16142247 # Tossing G: 99mTc-ciprofloxacin DRAXIMAGE. IDrugs. 2004 Apr;7(4):374-9. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/15057643 (en)
http://linked.open...gy/drugbank/group
  • investigational (en)
http://linked.open...ugbank/indication
  • Investigated for use/treatment in infectious and parasitic disease (unspecified). (en)
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Title
  • 99mTc-ciprofloxacin (en)
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http://linked.open...mechanismOfAction
  • Ciprofloxacin is a fluoroquinolone antibiotic. The mechanism of action of these fluoroquinolones is not fully understood, but it has been postulated that the interaction of ciprofloxacin with bacterial DNA gyrase (a type II topoisomerase) prevents DNA uncoiling and subsequent DNA synthesis within bacteria. Ciprofloxacin demonstrates a significant antibiotic effect for both gram-negative and gram-positive bacteria in either stationary or growth phases of bacterial replication. However, the addition of the 99mTc atom likely affects the interaction of the ciprofloxacin molecule with the enzyme. (en)
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