About: NCX 701     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

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http://linked.open...gbank/description
  • Nitroparacetamol (NCX-701) is a newly synthesized nitric oxide-releasing derivative of paracetamol. (en)
http://linked.open...generalReferences
  • # al-Swayeh OA, Futter LE, Clifford RH, Moore PK: Nitroparacetamol exhibits anti-inflammatory and anti-nociceptive activity. Br J Pharmacol. 2000 Aug;130(7):1453-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10928944 # Romero-Sandoval EA, Mazario J, Howat D, Herrero JF: NCX-701 (nitroparacetamol) is an effective antinociceptive agent in rat withdrawal reflexes and wind-up. Br J Pharmacol. 2002 Mar;135(6):1556-62. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/11906970 (en)
http://linked.open...gy/drugbank/group
  • investigational (en)
http://linked.open...ugbank/indication
  • Investigated for use/treatment in pain (acute or chronic). (en)
sameAs
Title
  • NCX 701 (en)
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http://linked.open...mechanismOfAction
  • NCX-701 (nitroparacetamol) is a NO-releasing derivative of paracetamol (acetaminophen) that has shown potent antinociceptive and anti-inflammatory properties. NCX-701 induces a potent antinociceptive effect by a mechanism different from and complementary to that of paracetamol, and its action is mainly located within the spinal cord in monoarthritic animals. (en)
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