About: QS-21

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	QS-21 is an investigational adjuvant, which is a substance added to vaccines and other immunotherapies that is designed to enhance the body’s immune response to the antigen contained within the treatment. It is the leading member of the Stimulon family of adjuvants. As a vaccine additive, it is currently being evaluated in clinical trials in a variety of disease areas by Antigenics. (en)
http://linked.open...generalReferences	# Cox J, Coulter A: Prospects for the development of new vaccine adjuvants. BioDrugs. 1999 Dec;12(6):439-53. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/18031193 # Gilewski TA, Ragupathi G, Dickler M, Powell S, Bhuta S, Panageas K, Koganty RR, Chin-Eng J, Hudis C, Norton L, Houghton AN, Livingston PO: Immunization of high-risk breast cancer patients with clustered sTn-KLH conjugate plus the immunologic adjuvant QS-21. Clin Cancer Res. 2007 May 15;13(10):2977-85. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17504999 (en)
http://linked.open...gy/drugbank/group	investigational (en)
http://linked.open...ugbank/indication	Investigated for use/treatment in genital herpes, HIV infection, hepatitis (viral, B), influenza, malaria, melanoma, and viral infection. (en)
sameAs	QS-21
Title	QS-21 (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB05400/identifier/drugbank/DB05400 http://linked.opendata.cz/resource/drugbank/drug/DB05400/identifier/pubchem-compound/60866 http://linked.opendata.cz/resource/drugbank/drug/DB05400/identifier/wikipedia/QS21
http://linked.open...mechanismOfAction	QS-21 has the potential ability to increase total vaccine-specific antibody response and T-cell response. In addition, QS-21 appears to increase potency of the vaccine with relatively small quantities of antigen and to exhibit synergy with other adjuvants. Because of the ability of QS-21 to improve the body’s immune response to very low doses of antigen, vaccine antigen may be ‘spared,’ which could significantly decrease the amount of antigen required for a given dose and make vaccine production more economical. (en)
http://linked.open...Molecular-Formula	http://linked.opendata.cz/resource/drugbank/property/271B42BB-363D-11E5-9242-09173F13E4C5
http://linked.open.../Molecular-Weight	http://linked.opendata.cz/resource/drugbank/property/271B42BA-363D-11E5-9242-09173F13E4C5

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