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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

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  • DN-101 is produced by Novacea Inc. OHSU and Beer have significant financial interest in Novacea Inc., a company that has a commercial interest in the results of this research and technology. It is a newly formulated pill that contains high amounts of calcitriol, a naturally occurring hormone and the biologically active form of vitamin D. (en)
http://linked.open...generalReferences
  • # Brawer MK: Recent Progress in the Treatment of Advanced Prostate Cancer With Intermittent Dose-Intense Calcitriol (DN-101). Rev Urol. 2007 Winter;9(1):1-8. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17396166 # Beer TM, Javle M, Lam GN, Henner WD, Wong A, Trump DL: Pharmacokinetics and tolerability of a single dose of DN-101, a new formulation of calcitriol, in patients with cancer. Clin Cancer Res. 2005 Nov 1;11(21):7794-9. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/16278401 (en)
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  • investigational (en)
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  • Investigated for use/treatment in cancer/tumors (unspecified), lung cancer, myelodysplastic syndrome, and prostate cancer. (en)
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Title
  • DN-101 (en)
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http://linked.open...mechanismOfAction
  • DN-101 delivers activated vitamin D in amounts that are far higher than the natural levels of this hormone. DN-101 provides Myelodysplastic Syndrome (MDS)MDS patients with high doses of calcitriol in a pill form. DN-101 in combination with docetaxel seems to improve overall survival and, interestingly, has a favorable safety profile compared with docetaxel alone. (en)
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