About: Methsuximide

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About: Methsuximide Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	Mesuximide (or methsuximide) is an anticonvulsant medication. It is sold by Pfizer under the name Petinutin. [Wikipedia] (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B3ECB-363D-11E5-9242-09173F13E4C5
http://linked.open...generalReferences	# Hurst DL: Methsuximide therapy of juvenile myoclonic epilepsy. Seizure. 1996 Mar;5(1):47-50. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/8777552 # Besag FM, Berry DJ, Pool F: Methsuximide lowers lamotrigine blood levels: A pharmacokinetic antiepileptic drug interaction. Epilepsia. 2000 May;41(5):624-7. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10802770 (en)
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...drugbank/halfLife	1.4-2.6 hours for mesuximide and 28-38 hours for the active metabolite. (en)
http://linked.open...ugbank/indication	For the control of absence (petit mal) seizures that are refractory to other drugs. (en)
sameAs	Methsuximide
Title	Methsuximide (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB05246/identifier/chemspider/6231 http://linked.opendata.cz/resource/drugbank/drug/DB05246/identifier/drugbank/DB05246 http://linked.opendata.cz/resource/drugbank/drug/DB05246/identifier/national-drug-code-directory/0071-0525-24 http://linked.opendata.cz/resource/drugbank/drug/DB05246/identifier/pubchem-compound/6476 http://linked.opendata.cz/resource/drugbank/drug/DB05246/identifier/pubchem-substance/46505339 http://linked.opendata.cz/resource/drugbank/drug/DB05246/identifier/pharmgkb/PA164743145 http://linked.opendata.cz/resource/drugbank/drug/DB05246/identifier/wikipedia/Methsuximide
http://linked.open...mechanismOfAction	Binds to T-type voltage sensitive calcium channels. Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1G gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by mibefradil. A particularity of this type of channels is an opening at quite negative potentials and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes. (en)
http://linked.open...drugbank/packager	3m pharmaceuticals inc Cardinal Health Pfizer Inc.
http://linked.open.../drugbank/synonym	Mesuximide (en) Celontin (en) (RS)-1,3-Dimethyl-3-phenyl-2,5-pyrrolidindion (en) 1,3-Dimethyl-3-phenyl-2,5-dioxopyrrolidine (en) 1,3-Dimethyl-3-phenyl-2,5-pyrrolidinedione (en) 1,3-Dimethyl-3-phenyl-pyrrolidin-2,5-dione (en) 1,3-Dimethyl-3-phenylsuccinimide (en) Alpha-methyl-alpha-phenyl n-methyl succinimide (en) Alpha-methylphensuximide (en) Methsuximid (en) Metsuccimide (en) N,2-Dimethyl-2-phenylsuccinimide (en) N-methyl-alpha-methyl-alpha-phenylsuccinimide (en) Mesuximida (en) Mesuximidum (en) Metosuccimmide (en)
http://linked.open...drugbank/toxicity	Acute overdoses may produce nausea, vomiting, and CNS depression including coma with respiratory depression. Levels greater than 40 µg/mL have caused toxicity and coma has been seen at levels of 150 µg/mL. (en)
http://linked.open...k/foodInteraction	Avoid alcohol (en) Take with food (en)
foaf:page	http://www.drugs.com/cdi/methsuximide.html http://www.rxlist.com/cgi/generic/methsuximide.htm
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http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	77-41-8 (en)
http://linked.open...drugbank/category	(en)
http://linked.open...gbank/containedIn	Celontin 300 mg Capsule Celontin 300 mg kapseal
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