About: OXI4503

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	OXI4503 is investigated in clinical trials for treating cancer/tumors. OXI4503 is a solid. OXI4503 blocks and destroys tumor vasculature, resulting in extensive tumor cell death and necrosis. OXI4503 (combretastatin A1 di-phosphate / CA1P) is a unique and highly potent, dual-mechanism vascular disrupting agent (VDA). In addition, however, preclinical data demonstrates that OXI4503 is metabolized by oxidative enzymes (e.g., tyrosinase and peroxidases), which are elevated in many solid tumors and tumor infiltrates, to an orthoquinone chemical species that has direct cytotoxic effects on tumor cells. Preclinical studies have demonstrated that OXI4503 has (i) single-agent activity against a range of xenograft tumor models; and (ii) synergistic or additive effects when incorporated in various combination regimens with chemotherapy, molecularly-targeted therapies (including tumor-angiogenesis inhibitors), and radiation therapy. (en)
http://linked.open...generalReferences	# Chan LS, Malcontenti-Wilson C, Muralidharan V, Christophi C: Alterations in vascular architecture and permeability following OXi4503 treatment. Anticancer Drugs. 2008 Jan;19(1):17-22. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/18043126 # Hokland SL, Horsman MR: The new vascular disrupting agent combretastatin-A1-disodium-phosphate (OXi4503) enhances tumour response to mild hyperthermia and thermoradiosensitization. Int J Hyperthermia. 2007 Nov;23(7):599-606. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/18038290 # Chan LS, Malcontenti-Wilson C, Muralidharan V, Christophi C: Effect of vascular targeting agent Oxi4503 on tumor cell kinetics in a mouse model of colorectal liver metastasis. Anticancer Res. 2007 Jul-Aug;27(4B):2317-23. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17695520 # Salmon HW, Siemann DW: Effect of the second-generation vascular disrupting agent OXi4503 on tumor vascularity. Clin Cancer Res. 2006 Jul 1;12(13):4090-4. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/16818709 (en)
http://linked.open...gy/drugbank/group	investigational (en)
http://linked.open...ugbank/indication	Investigated for use/treatment in cancer/tumors (unspecified). (en)
sameAs	OXI4503
Title	OXI4503 (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB05143/identifier/bindingdb/50236033 http://linked.opendata.cz/resource/drugbank/drug/DB05143/identifier/chemspider/5293742 http://linked.opendata.cz/resource/drugbank/drug/DB05143/identifier/drugbank/DB05143 http://linked.opendata.cz/resource/drugbank/drug/DB05143/identifier/pubchem-compound/6918545
http://linked.open...mechanismOfAction	OXi4503 blocks and destroys tumor vasculature, resulting in extensive tumor cell death and necrosis. It induced the shutdown of tumor blood vessels and affected peripheral tumor regions less than central regions. (en)
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http://linked.open...casRegistryNumber	288847-35-8 (en)
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