About: Oxibendazole     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
http://linked.open...gbank/description
  • Oxibendazole is a polymerase inhibitor in phase III trials for the treatment of helminth intestinal infections. (en)
http://linked.open...generalReferences
  • # Gokbulut C, Nolan AM, McKellar QA: Plasma disposition, faecal excretion and in vitro metabolism of oxibendazole following oral administration in horses. Res Vet Sci. 2002 Feb;72(1):11-5. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/12002632 # Magambo JK: Ultrastructural changes in Ascaris suum after oxibendazole treatment. Afr J Health Sci. 1998 Feb;5(1):38-41. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17580993 (en)
http://linked.open...gy/drugbank/group
  • investigational (en)
http://linked.open...ugbank/indication
  • Investigated for use/treatment in infectious and parasitic disease (unspecified) and pediatric indications. (en)
sameAs
Title
  • Oxibendazole (en)
adms:identifier
http://linked.open...mechanismOfAction
  • Oxibendazole causes degenerative alterations in the tegument and intestinal cells of the worm by binding to the colchicine-sensitive site of tubulin, thus inhibiting its polymerization or assembly into microtubules. The loss of the cytoplasmic microtubules leads to impaired uptake of glucose by the larval and adult stages of the susceptible parasites, and depletes their glycogen stores. Degenerative changes in the endoplasmic reticulum, the mitochondria of the germinal layer, and the subsequent release of lysosomes result in decreased production of adenosine triphosphate (ATP), which is the energy required for the survival of the helminth. Due to diminished energy production, the parasite is immobilized and eventually dies. (en)
http://linked.open.../drugbank/synonym
  • (5-Propoxy-1H-benzimidazol-2-yl)carbamic acid methyl ester (en)
  • Methyl (5-propoxy-1H-benzimidazol-2-yl)carbamate (en)
  • Methyl 5-n-propoxy-2-benzimidazole carbamate (en)
  • Methyl 5-propoxy-2-benzimidazolecarbamate (en)
  • OBZ (en)
  • Oxibendazolo (en)
  • Oxibendazolum (en)
  • Oxybendazole (en)
  • methyl 5-[n-propoxy]benzimidazole-2-carbamate (en)
  • 5-Propoxy-2-benzimidazolecarbamic acid methyl ester (en)
http://linked.open...ugbank/IUPAC-Name
http://linked.open...gy/drugbank/InChI
http://linked.open...Molecular-Formula
http://linked.open.../Molecular-Weight
http://linked.open...noisotopic-Weight
http://linked.open...y/drugbank/SMILES
http://linked.open.../Water-Solubility
http://linked.open...ogy/drugbank/logP
http://linked.open...ogy/drugbank/logS
http://linked.open...nd-Acceptor-Count
http://linked.open...-Bond-Donor-Count
http://linked.open...drugbank/InChIKey
http://linked.open...urface-Area--PSA-
http://linked.open...nk/Polarizability
http://linked.open...bank/Refractivity
http://linked.open...atable-Bond-Count
http://linked.open.../affectedOrganism
  • Helminthic Microorganisms (en)
http://linked.open...casRegistryNumber
  • 20559-55-1 (en)
http://linked.open...drugbank/category
  • (en)
http://linked.open...k/Bioavailability
http://linked.open...bank/Ghose-Filter
http://linked.open...nk/MDDR-Like-Rule
http://linked.open...ank/Melting-Point
http://linked.open...k/Number-of-Rings
http://linked.open...siological-Charge
http://linked.open...bank/Rule-of-Five
http://linked.open...tional-IUPAC-Name
http://linked.open...strongest-acidic-
http://linked.open...-strongest-basic-
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