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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

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http://linked.open...gbank/description
  • Bicifadine (DOV-220075) is a nonopioid analgesic. It is an inhibitor of both the norepinephrine and serotonin transporters and an NMDA antagonist with a non-narcotic profile. Bicifadine was shown to have potent analgesic activity in vivo and was chosen for further development for the treatment of pain. (en)
http://linked.open...generalReferences
  • # Basile AS, Janowsky A, Golembiowska K, Kowalska M, Tam E, Benveniste M, Popik P, Nikiforuk A, Krawczyk M, Nowak G, Krieter PA, Lippa AS, Skolnick P, Koustova E: Characterization of the antinociceptive actions of bicifadine in models of acute, persistent, and chronic pain. J Pharmacol Exp Ther. 2007 Jun;321(3):1208-25. Epub 2007 Feb 26. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17325229 # Erickson DA, Hollfelder S, Tenge J, Gohdes M, Burkhardt JJ, Krieter PA: In Vitro Metabolism of the Analgesic Bicifadine in the Mouse, Rat, Monkey, and Human. Drug Metab Dispos. 2007 Sep 19;. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17881661 (en)
http://linked.open...gy/drugbank/group
  • investigational (en)
http://linked.open...ugbank/indication
  • For the treatment of pain. (en)
sameAs
Title
  • Bicifadine (en)
adms:identifier
http://linked.open...mechanismOfAction
  • Preclinical studies and clinical trials indicate that bicifadine's analgesic properties result through the enhancement and prolongation of norepinephrine and serotonin actions, however other actions may be involved. (en)
http://linked.open...ogy/drugbank/salt
  • (en)
http://linked.open...ugbank/IUPAC-Name
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  • Humans and other mammals (en)
http://linked.open...casRegistryNumber
  • 71195-57-8 (en)
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http://linked.open...-strongest-basic-
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