About: Calanolide A

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	Calanolide A is a new non-nucleoside reverse transcriptase inhibitor (NNRTI) derived from a plant found in the Malaysian rain forest. A related compound, calanolide B, also has anti-HIV activity. Both drugs are being developed by Sarawak Pharmaceuticals. A preliminary dosing study among HIV-infected individuals showed a significant antiviral effect compared with placebo. (en)
http://linked.open...generalReferences	# Eiznhamer DA, Creagh T, Ruckle JL, Tolbert DT, Giltner J, Dutta B, Flavin MT, Jenta T, Xu ZQ: Safety and pharmacokinetic profile of multiple escalating doses of (+)-calanolide A, a naturally occurring nonnucleoside reverse transcriptase inhibitor, in healthy HIV-negative volunteers. HIV Clin Trials. 2002 Nov-Dec;3(6):435-50. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/12501127 # Xu ZQ, Barrow WW, Suling WJ, Westbrook L, Barrow E, Lin YM, Flavin MT: Anti-HIV natural product (+)-calanolide A is active against both drug-susceptible and drug-resistant strains of Mycobacterium tuberculosis. Bioorg Med Chem. 2004 Mar 1;12(5):1199-207. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/14980631 # Sekino E, Kumamoto T, Tanaka T, Ikeda T, Ishikawa T: Concise synthesis of anti-HIV-1 active (+)-inophyllum B and (+)-calanolide A by application of (-)-quinine-catalyzed intramolecular oxo-Michael addition. J Org Chem. 2004 Apr 16;69(8):2760-7. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/15074925 (en)
http://linked.open...gy/drugbank/group	investigational (en)
http://linked.open...drugbank/halfLife	20 hours for 800mg (en)
http://linked.open...ugbank/indication	For use in combination treatment of HIV infection (AIDS). (en)
sameAs	Calanolide A
Title	Calanolide A (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB04886/identifier/bindingdb/50002662 http://linked.opendata.cz/resource/drugbank/drug/DB04886/identifier/chemspider/58497 http://linked.opendata.cz/resource/drugbank/drug/DB04886/identifier/drugbank/DB04886 http://linked.opendata.cz/resource/drugbank/drug/DB04886/identifier/kegg-compound/C09147 http://linked.opendata.cz/resource/drugbank/drug/DB04886/identifier/pubchem-compound/64972 http://linked.opendata.cz/resource/drugbank/drug/DB04886/identifier/pubchem-substance/11339
http://linked.open...mechanismOfAction	Viral life-cycle studies indicate that calanolide A acts early in the infection process, similar to the known HIV reverse transcriptase (RT) inhibitor 2', 3'-dideoxycytidine. In enzyme inhibition assays, calanolide A potently and selectively inhibits recombinant HIV type 1 RT but not cellular DNA polymerases or HIV type 2 RT within the concentration range tested. (en)
http://linked.open.../drugbank/synonym	(+)-calanolide A (en) (+/-)-calanolide A (en)
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http://linked.open.../affectedOrganism	Human Immunodeficiency Virus (en)
http://linked.open...casRegistryNumber	142632-32-4 (en)
http://linked.open...drugbank/category	(en)
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