About: Homoharringtonine     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

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http://linked.open...gbank/description
  • Homoharringtonine, AKA HHT or omacetaxine mepesuccinate, is a cephalotaxine ester and protein synthesis inhibitor with established clinical activity as a single agent in hematological malignancies. Homoharringtonine is synthesized from cephalotaxine, which is an extract from the leaves of the plant, Cephalotaxus species. In October 2005, homoharringtonine received Orphan Drug designation from the EMEA for the treatment of chronic myeloid leukemia (CML). Then in March 2006, homoharringtonine received Orphan Drug status from the FDA for the treatment of CML. In November 2006, homoharringtonine, for the treatment of CML, was granted Fast Track designation by the FDA. Most recently, in October 2012, homoharringtonine was marketed under the brand name Synribo™ and FDA approved for patients who are intolerant and/or resistant to two or more tyrosine kinase inhibitors used to treat accelerated or chronic phase CML. (en)
http://linked.open...y/drugbank/dosage
http://linked.open...generalReferences
  • # Lou YJ, Qian WB, Jin J: Homoharringtonine induces apoptosis and growth arrest in human myeloma cells. Leuk Lymphoma. 2007 Jul;48(7):1400-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17613769 # Jie H, Donghua H, Xingkui X, Liang G, Wenjun W, Xiaoyan H, Zhen C: Homoharringtonine-induced apoptosis of MDS cell line MUTZ-1 cells is mediated by the endoplasmic reticulum stress pathway. Leuk Lymphoma. 2007 May;48(5):964-77. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17487741 # FDA label. (en)
http://linked.open...gy/drugbank/group
  • approved (en)
http://linked.open...drugbank/halfLife
  • Homoharringtonine has a half life of about 6 hours after subcutaneous administration. (en)
http://linked.open...ugbank/indication
  • Used in patients who are intolerant and/or resistant to two or more tyrosine kinase inhibitors used to treat accelerated or chronic phase CML. (en)
sameAs
Title
  • Homoharringtonine (en)
adms:identifier
http://linked.open...mechanismOfAction
  • Homoharringtonine inhibits protein synthesis by not directly binding to Bcr-Abl. It binds to the A-site cleft in the large ribosomal subunit, which affects chain elongation and prevents protein synthesis. (en)
http://linked.open...outeOfElimination
  • The main route of elimination for homoharringtonine is still unknown, but renal elimination is less than 15%. (en)
http://linked.open.../drugbank/synonym
  • CGX-635 (en)
  • Cephalotaxus alkaloid (en)
  • HHT (en)
  • Myelostat (en)
  • omacetaxine mepesuccinate (en)
http://linked.open...drugbank/toxicity
  • The most severe adverse effects after homoharringtonine administration are myelosuppression, bleeding, hyperglycemia, and fetal harm. (en)
http://linked.open...umeOfDistribution
  • Homoharringtonine has a steady state Vd of 141 ± 93.4 L. (en)
http://linked.open...k/foodInteraction
  • Homoharringtonine is administered subcutaneously, so food should have no effects. (en)
http://linked.open...nk/proteinBinding
  • Plasma protein binding is equal or less than 50%. (en)
http://linked.open...ynthesisReference
  • Yaguang Liu, "Process for producing harringtonine and homoharringtonine." U.S. Patent US4783454, issued June, 1980. (en)
foaf:page
http://linked.open...ugbank/IUPAC-Name
http://linked.open...gy/drugbank/InChI
http://linked.open...Molecular-Formula
http://linked.open.../Molecular-Weight
http://linked.open...noisotopic-Weight
http://linked.open...y/drugbank/SMILES
http://linked.open.../Water-Solubility
http://linked.open...ogy/drugbank/logP
http://linked.open...ogy/drugbank/logS
http://linked.open...l/drug/hasATCCode
http://linked.open...nd-Acceptor-Count
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http://linked.open...drugbank/InChIKey
http://linked.open...urface-Area--PSA-
http://linked.open...nk/Polarizability
http://linked.open...bank/Refractivity
http://linked.open...atable-Bond-Count
http://linked.open...ugbank/absorption
  • Homoharringtonine absorption was not quantified, but maximum concentration is reached after about 30 mins. (en)
http://linked.open.../affectedOrganism
  • Humans and other mammals (en)
http://linked.open...casRegistryNumber
  • 26833-87-4 (en)
http://linked.open...drugbank/category
  • (en)
http://linked.open...rugbank/clearance
  • Clearance for homoharringtonine was not quantified. (en)
http://linked.open...k/Bioavailability
http://linked.open...bank/Ghose-Filter
http://linked.open...nk/MDDR-Like-Rule
http://linked.open...k/Number-of-Rings
http://linked.open...siological-Charge
http://linked.open...bank/Rule-of-Five
http://linked.open...tional-IUPAC-Name
http://linked.open...strongest-acidic-
http://linked.open...-strongest-basic-
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