About: Zimelidine

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	Zimelidine has been banned worldwide due to serious, sometimes fatal, cases of central and/or peripheral neuropathy known as Guillain-Barré syndrome and due to a peculiar hypersensitivity reaction involving many organs including skin exanthema, flu-like symptoms, arthralgias, and sometimes eosinophilia. Additionally, zimelidine was charged to cause an increase in suicidal ideation and/or attempts among depressive patients. After its ban, it was succeeded by fluvoxamine and fluoxetine (derived from the antihistamine diphenhydramine) in that order, and the other SSRIs. (en)
http://linked.open...generalReferences	# Caille G, Kouassi E, de Montigny C: Pharmacokinetic study of zimelidine using a new GLC method. Clin Pharmacokinet. 1983 Nov-Dec;8(6):530-40. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/6228368 # Godbout R, Montplaisir J: The effect of zimelidine, a serotonin-reuptake blocker, on cataplexy and daytime sleepiness of narcoleptic patients. Clin Neuropharmacol. 1986;9(1):46-51. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/2950994 (en)
http://linked.open...gy/drugbank/group	withdrawn (en)
http://linked.open...drugbank/halfLife	8.4 +/- 2.0 hours for the parent compound and 19.4 +/- 3.6 hours for norzimelidine. (en)
http://linked.open...ugbank/indication	For the treatment of depression. (en)
sameAs	Zimelidine
Title	Zimelidine (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB04832/identifier/chemspider/38293 http://linked.opendata.cz/resource/drugbank/drug/DB04832/identifier/drugbank/DB04832 http://linked.opendata.cz/resource/drugbank/drug/DB04832/identifier/pubchem-compound/5365247 http://linked.opendata.cz/resource/drugbank/drug/DB04832/identifier/pubchem-substance/46504589 http://linked.opendata.cz/resource/drugbank/drug/DB04832/identifier/wikipedia/Zimelidine
http://linked.open...mechanismOfAction	The antidepressant actions of zimelidine are presumed to be linked to its inhibition of CNS neuronal uptake of serotonin. Zimelidine blocks the reuptake of serotonin at the serotonin reuptake pump of the neuronal membrane, enhancing the actions of serotonin on 5HT1A autoreceptors. SSRIs bind with significantly less affinity to histamine, acetylcholine, and norepinephrine receptors than tricyclic antidepressant drugs. (en)
http://linked.open.../drugbank/synonym	Zimeldine (en) (Z)-3-(4'-Bromophenyl)-3-(3''-pyridyl)dimethylallylamine (en) (z)-zimelidine (en) Cis-zimelidine (en) (Z)-3-[1-(p-Bromophenyl)-3-(dimethylamino)propenyl]pyridine (en)
http://linked.open...ugbank/IUPAC-Name	http://linked.opendata.cz/resource/drugbank/property/271B57E1-363D-11E5-9242-09173F13E4C5
http://linked.open...gy/drugbank/InChI	http://linked.opendata.cz/resource/drugbank/property/271B57E7-363D-11E5-9242-09173F13E4C5
http://linked.open...Molecular-Formula	http://linked.opendata.cz/resource/drugbank/property/271B57E6-363D-11E5-9242-09173F13E4C5
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http://linked.open...noisotopic-Weight	http://linked.opendata.cz/resource/drugbank/property/271B57E4-363D-11E5-9242-09173F13E4C5
http://linked.open...y/drugbank/SMILES	http://linked.opendata.cz/resource/drugbank/property/271B57E5-363D-11E5-9242-09173F13E4C5
http://linked.open.../Water-Solubility	http://linked.opendata.cz/resource/drugbank/property/271B57DF-363D-11E5-9242-09173F13E4C5
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http://linked.open...ogy/drugbank/logS	http://linked.opendata.cz/resource/drugbank/property/271B57DE-363D-11E5-9242-09173F13E4C5
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http://linked.open...-Bond-Donor-Count	http://linked.opendata.cz/resource/drugbank/property/271B57EE-363D-11E5-9242-09173F13E4C5
http://linked.open...drugbank/InChIKey	http://linked.opendata.cz/resource/drugbank/property/271B57E8-363D-11E5-9242-09173F13E4C5
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http://linked.open...nk/Polarizability	http://linked.opendata.cz/resource/drugbank/property/271B57EB-363D-11E5-9242-09173F13E4C5
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http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	56775-88-3 (en)
http://linked.open...drugbank/category	(en)
http://linked.open...k/Bioavailability	http://linked.opendata.cz/resource/drugbank/property/271B57F2-363D-11E5-9242-09173F13E4C5
http://linked.open...bank/Ghose-Filter	http://linked.opendata.cz/resource/drugbank/property/271B57F4-363D-11E5-9242-09173F13E4C5
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http://linked.open...siological-Charge	http://linked.opendata.cz/resource/drugbank/property/271B57F0-363D-11E5-9242-09173F13E4C5
http://linked.open...bank/Rule-of-Five	http://linked.opendata.cz/resource/drugbank/property/271B57F3-363D-11E5-9242-09173F13E4C5
http://linked.open...tional-IUPAC-Name	http://linked.opendata.cz/resource/drugbank/property/271B57E2-363D-11E5-9242-09173F13E4C5
http://linked.open...-strongest-basic-	http://linked.opendata.cz/resource/drugbank/property/271B57EF-363D-11E5-9242-09173F13E4C5

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