About: Bifonazole

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About: Bifonazole Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	Bifonazole is an azole antifungal drug. [Wikipedia] (en)
http://linked.open...generalReferences	# Watanabe S, Takahashi H, Nishikawa T, Takiuchi I, Higashi N, Nishimoto K, Kagawa S, Yamaguchi H, Ogawa H: A comparative clinical study between 2 weeks of luliconazole 1% cream treatment and 4 weeks of bifonazole 1% cream treatment for tinea pedis. Mycoses. 2006 May;49(3):236-41. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/16681817 # Cho KJ, Su W, Chen WC, Law YP, Fang HC, Liu CP, Cheng JS, Lee KC, Lo YK, Chang HT, Huang JK, Jan CR: Mechanism of bifonazole-induced [Ca2+]i increases in MDCK renal tubular cells. Chin J Physiol. 2001 Sep 30;44(3):97-101. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/11767287 # Tanuma H, Doi M, Sato N, Nishiyama S, Abe M, Kume H, Katsuoka K: Bifonazole (Mycospor cream) in the treatment of moccasin-type tinea pedis. Comparison between combination therapy of bifonazole cream + 10% urea ointment (Urepearl) and occlusive dressing therapy with the same agents. Mycoses. 2000;43(3-4):129-37. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10907343 # Berg D, Regel E, Harenberg HE, Plempel M: Bifonazole and clotrimazole. Their mode of action and the possible reason for the fungicidal behaviour of bifonazole. Arzneimittelforschung. 1984;34(2):139-46. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/6372801 (en)
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...drugbank/halfLife	1-2 hours (en)
http://linked.open...ugbank/indication	Used for the treatment of various topical fungal infections, including athlete's foot (tinea pedis). (en)
sameAs	Bifonazole
Title	Bifonazole (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB04794/identifier/bindingdb/50128548 http://linked.opendata.cz/resource/drugbank/drug/DB04794/identifier/chemspider/2287 http://linked.opendata.cz/resource/drugbank/drug/DB04794/identifier/drugbank/DB04794 http://linked.opendata.cz/resource/drugbank/drug/DB04794/identifier/pdb/TMI http://linked.opendata.cz/resource/drugbank/drug/DB04794/identifier/pubchem-compound/2378 http://linked.opendata.cz/resource/drugbank/drug/DB04794/identifier/pubchem-substance/46507284 http://linked.opendata.cz/resource/drugbank/drug/DB04794/identifier/pharmgkb/PA164746464 http://linked.opendata.cz/resource/drugbank/drug/DB04794/identifier/wikipedia/Bifonazole
http://linked.open...mechanismOfAction	Bifonazole works by inhibiting the production of a substance called ergosterol, which is an essential component of fungal cell membranes.It acts to destabilize the fungal cyctochrome p450 51 enzyme (also known as Lanosterol 14-alpha demethylase). This is vital in the cell membrance structure of the fungus. Its inhibition leads to cell lysis. The disruption in production of ergosterol disrupts the cell membrane and causes holes to appear. The cell membranes of fungi are vital for their survival. They keep unwanted substances from entering the cells and stop the contents of the cells from leaking out. As bifonazole causes holes to appear in the cell membranes, essential constituents of the fungal cells can leak out. This kills the fungi. (en)
http://linked.open.../drugbank/synonym	Mycospor (en) (+-)-1-(p,alpha-Diphenylbenzyl)imidazole (en) 1-((4-Biphenylyl)phenylmethyl)-1H-imidazole (en) 1-(alpha-(4-Biphenylyl)benzyl)imidazole (en) 1-(p,alpha-Diphenylbenzyl)imidazole (en) Bay h 4502 (en) Trifonazole (en) (+-)1-([1,1'-Biphenyl]-4-ylphenylmethyl)-1H-imidazole (en) Bifonazol (en) Bifonazolum (en)
http://linked.open...ynthesisReference	Regal, E., Draber, W., Buchel, K.H.and Plempel, M.; U.S. Patent 4,118,487; October 3,1978; assigned to Bayer A.G. (en)
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http://linked.open...l/drug/hasATCCode	Bifonazole
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http://linked.open...ugbank/absorption	Very low absorption following topical administration (0.6% of an applied dose). In cases of skin lesions absorption is increased (2.5%). (en)
http://linked.open.../affectedOrganism	Fungi (en)
http://linked.open...casRegistryNumber	60628-96-8 (en)
http://linked.open...drugbank/category	(en)
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