About: Estriol

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	A hydroxylated metabolite of estradiol or estrone that has a hydroxyl group at C3-beta, 16-alpha, and 17-beta position. Estriol is a major urinary estrogen. During pregnancy, large amount of estriol is produced by the placenta. Isomers with inversion of the hydroxyl group or groups are called epiestriol. Though estriol is used as part of the primarily North American phenomenon of bioidentical hormone replacement therapy, it is not approved for use by the FDA or Health Canada. It is however available in the United States by prescription filled only by compounding pharmacies. It has also been approved and marketed throughout Europe and Asia for approximately 40 years for the treatment of post-menopausal hot flashes. (en)
http://linked.open...generalReferences	# Soldan SS, Alvarez Retuerto AI, Sicotte NL, Voskuhl RR: Immune modulation in multiple sclerosis patients treated with the pregnancy hormone estriol. J Immunol. 2003 Dec 1;171(11):6267-74. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/14634144 # "Trimesta":http://www.syntheticbiologics.com/trimesta (en)
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...ugbank/indication	Used as a test to determine the general health of an unborn fetus. (en)
sameAs	Estriol
Title	Estriol (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB04573/identifier/chebi/27974 http://linked.opendata.cz/resource/drugbank/drug/DB04573/identifier/chemspider/5553 http://linked.opendata.cz/resource/drugbank/drug/DB04573/identifier/drugbank/DB04573 http://linked.opendata.cz/resource/drugbank/drug/DB04573/identifier/kegg-compound/C05141 http://linked.opendata.cz/resource/drugbank/drug/DB04573/identifier/kegg-drug/D00185 http://linked.opendata.cz/resource/drugbank/drug/DB04573/identifier/pdb/ESL http://linked.opendata.cz/resource/drugbank/drug/DB04573/identifier/pubchem-compound/5756 http://linked.opendata.cz/resource/drugbank/drug/DB04573/identifier/pubchem-substance/46505881 http://linked.opendata.cz/resource/drugbank/drug/DB04573/identifier/pharmgkb/PA164769104 http://linked.opendata.cz/resource/drugbank/drug/DB04573/identifier/wikipedia/Estriol
http://linked.open...mechanismOfAction	Estriol levels can be measured to give an indication of the general health of the fetus. DHEA-S is produced by the adrenal cortex of the fetus. This is converted to estriol by the placenta. If levels of "unconjugated estriol" are abnormally low in a pregnant woman, this may indicate a problem with the development of the child. The drug interacts with a target cell receptor. When the estrogen receptor has bound its ligand it can enter the nucleus of the target cell, and regulate gene transcription which leads to formation of messenger RNA. The mRNA interacts with ribosomes to produce specific proteins that express the effect of estriol upon the target cell. Estrogens increase the hepatic synthesis of sex hormone binding globulin (SHBG), thyroid-binding globulin (TBG), and other serum proteins and suppress follicle-stimulating hormone (FSH) from the anterior pituitary. (en)
http://linked.open...drugbank/packager	Amend A-S Medication Solutions LLC
http://linked.open.../drugbank/synonym	Estriol (en) (16α,17β)-estra-1,3,5(10)-triene-3,16,17-triol (en) 16-alpha-Hydroxyestradiol (en) 16alpha-hydroxyestradiol (en) 16α-hydroxyestradiol (en) Oestriol (en) 1,3,5(10)-Estratriene-3,16-alpha,17beta-triol (en) Deuslon-a (en) Estriel (en) Trihydroxyestrin (en) (16alpha,17beta)-Estra-1,3,5(10)-triene-3,16,17-triol (en) 3,16alpha,17beta-Trihydroxy-delta(1,3,5)-estratriene (en)
http://linked.open...drugbank/toxicity	ORAL (LD50): Acute: >2000 mg/kg [Rat]. (en)
http://linked.open...ogy/drugbank/salt	(en)
http://linked.open...ynthesisReference	James V. Freeman, Gary M. Johnson, "Synthesis of 6.alpha.-functionalized estriol haptens and protein conjugates thereof." U.S. Patent US5902888, issued June, 1973. (en)
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http://linked.open...l/drug/hasATCCode	Estriol Estriol
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http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	50-27-1 (en)
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http://linked.open...-strongest-basic-	http://linked.opendata.cz/resource/drugbank/property/271B3FB4-363D-11E5-9242-09173F13E4C5

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