| Attributes | Values |
|---|
| rdf:type
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| http://linked.open...gbank/description
| - Phenol is an antiseptic and disinfectant. It is active against a wide range of micro-organisms including some fungi and viruses, but is only slowly effective against spores. Phenol has been used to disinfect skin and to relieve itching. Phenol is also used as an oral analgesic or anesthetic in products such as Chloraseptic to treat pharyngitis. Additionally, phenol and its related compounds are used in surgical ingrown toenail treatment, a process termed phenolization. Research indicates that parental exposure to phenol and its related compounds are positively associated with spontaneous abortion. During the second world war, phenol injections were used as a means of execution by the Nazis. Phenol is a toxic compound whose vapours are corrosive to the skin, eyes, and respiratory tract. (en)
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| http://linked.open...y/drugbank/dosage
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| http://linked.open...generalReferences
| - # Chen X, Chen M, Xu B, Tang R, Han X, Qin Y, Xu B, Hang B, Mao Z, Huo W, Xia Y, Xu Z, Wang X: Parental phenols exposure and spontaneous abortion in Chinese population residing in the middle and lower reaches of the Yangtze River. Chemosphere. 2013 May 25. pii: S0045-6535(13)00665-6. doi: 10.1016/j.chemosphere.2013.04.067. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/23714150 # H. Babich, D.L. Davis, Phenol: A review of environmental and health risks. Regulatory Toxicology and Pharmacology, Volume 1, Issue 1, June 1981, Pages 90–109. # Gracies JM, Elovic E, McGuire J, Simpson DM: Traditional pharmacological treatments for spasticity. Part I: Local treatments. Muscle Nerve Suppl. 1997;6:S61-91. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/9826983 (en)
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| http://linked.open...gy/drugbank/group
| - approved (en)
- experimental (en)
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| http://linked.open...ugbank/indication
| - Phenol is primarily indicated for minor sore throat pain, sore mouth, minor mouth irritation, and pain associated with canker sores. Additionally, phenol is indicated in the treatment of focal spasticity. (en)
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| sameAs
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| Title
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| adms:identifier
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| http://linked.open...mechanismOfAction
| - Phenol is a potent proteolytic agent. Concentrations in the 5% to 7% range dissolve tissue on contact via proteolysis. In high concentrations when injected next to a nerve, phenol produces a chemical neurolysis which is nonselective across nerve fiber size and most prominent on its outer aspect. Local anesthetic effects occur within 5-10 minutes. (en)
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| http://linked.open...drugbank/packager
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| http://linked.open...outeOfElimination
| - The kidney is the primary route of elimination of phenol. (en)
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| http://linked.open.../drugbank/synonym
| - Phenol (en)
- Hydroxybenzene (en)
- Acide carbolique (en)
- Acide phenique (en)
- Benzenol (en)
- Carbolic acid (en)
- Carbolsaeure (en)
- Karbolsaeure (en)
- Monohydroxybenzene (en)
- Oxybenzene (en)
- PHOH (en)
- Phenic Acid (en)
- Phenyl alcohol (en)
- Phenyl hydroxide (en)
- Phenylic Acid (en)
- Phenylic alcohol (en)
|
| http://linked.open...drugbank/toxicity
| - Mouse, Subcutaneous, LD50: 0.3-0.35 g/kg. (Duplay and Cazin, 1891; Tollens, 1905). Rat, Subcutaneous, LD50: 0.45. (Deichmann and Witherup, 1944). Rat, Oral, LD50: 0.53. (Deichmann and Witherup, 1944). Rat, Oral, LD50: 0.65. (Flickinger, 1976). Rat, Cutaneous, LD50: 0.67. (Conning and Hayes, 1970). (en)
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| http://linked.open...umeOfDistribution
| - At I5 min after exposure, the liver contained the highest level of phenol, consisting mainly of free phenol. After 82 minutes post administration, phenol is uniformly distributed in the liver, blood, kidneys, lungs, along with the heart, testes, thymus and the spleen. With the passage of time, the proportion of free to conjugated phenol changed. By 360 minutes most phenol appears in conjugated forms. (en)
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| http://linked.open.../drugbank/mixture
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| http://linked.open...ynthesisReference
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| foaf:page
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| http://linked.open...ugbank/IUPAC-Name
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| http://linked.open...gy/drugbank/InChI
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| http://linked.open...Molecular-Formula
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| http://linked.open.../Molecular-Weight
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| http://linked.open...noisotopic-Weight
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| http://linked.open...y/drugbank/SMILES
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| http://linked.open.../Water-Solubility
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| http://linked.open...ogy/drugbank/logP
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| http://linked.open...ogy/drugbank/logS
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| http://linked.open...logy/drugbank/pKa
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| http://linked.open...l/drug/hasATCCode
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| http://linked.open...nd-Acceptor-Count
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| http://linked.open...-Bond-Donor-Count
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| http://linked.open...drugbank/InChIKey
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| http://linked.open...urface-Area--PSA-
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| http://linked.open...nk/Polarizability
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| http://linked.open...bank/Refractivity
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| http://linked.open...atable-Bond-Count
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| http://linked.open...ugbank/absorption
| - Phenol is rapidly absorbed through the skin and into the lungs. (en)
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| http://linked.open.../affectedOrganism
| - Humans and other mammals (en)
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| http://linked.open...casRegistryNumber
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| http://linked.open...drugbank/category
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| http://linked.open...rugbank/clearance
| - In rabbits, 72% is excreted in the urine, 1% in the feces, 4% in the carcass following sacrifice, and trace amounts were exhaled. (en)
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| http://linked.open...k/Bioavailability
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| http://linked.open...ank/Boiling-Point
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| http://linked.open...bank/Ghose-Filter
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| http://linked.open...nk/MDDR-Like-Rule
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| http://linked.open...ank/Melting-Point
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| http://linked.open...k/Number-of-Rings
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| http://linked.open...siological-Charge
| |
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