About: 2-Methoxyestradiol     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

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http://linked.open...gbank/description
  • 2-Methoxyestradiol (2ME2) is a drug that prevents the formation of new blood vessels that tumors need in order to grow (angiogenesis). It has undergone Phase 1 clinical trials against breast cancers. Preclinical models also suggest that 2ME2 could also be effective against inflammatory diseases such as rheumatoid arthritis. [Wikipedia] (en)
http://linked.open...generalReferences
  • # Schumacher G, Hoffmann J, Cramer T, Spinelli A, Jacob D, Bahra M, Pratschke J, Pfitzmann R, Schmidt S, Lage H: Antineoplastic activity of 2-methoxyestradiol in human pancreatic and gastric cancer cells with different multidrug-resistant phenotypes. J Gastroenterol Hepatol. 2007 Sep;22(9):1469-73. Epub 2007 Jul 20. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17645459 # Sutherland TE, Anderson RL, Hughes RA, Altmann E, Schuliga M, Ziogas J, Stewart AG: 2-Methoxyestradiol - a unique blend of activities generating a new class of anti-tumour/anti-inflammatory agents. Drug Discov Today. 2007 Jul;12(13-14):577-84. Epub 2007 Jun 26. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17631253 # Fong YC, Yang WH, Hsu SF, Hsu HC, Tseng KF, Hsu CJ, Lee CY, Scully SP: 2-methoxyestradiol induces apoptosis and cell cycle arrest in human chondrosarcoma cells. J Orthop Res. 2007 Aug;25(8):1106-14. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17415781 # Eichenlaub-Ritter U, Winterscheidt U, Vogt E, Shen Y, Tinneberg HR, Sorensen R: 2-methoxyestradiol induces spindle aberrations, chromosome congression failure, and nondisjunction in mouse oocytes. Biol Reprod. 2007 May;76(5):784-93. Epub 2007 Jan 17. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17229934 # Lakhani NJ, Sparreboom A, Xu X, Veenstra TD, Venitz J, Dahut WL, Figg WD: Characterization of in vitro and in vivo metabolic pathways of the investigational anticancer agent, 2-methoxyestradiol. J Pharm Sci. 2007 Jul;96(7):1821-31. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17252610 # Lakhani N, Sparreboom A, Venitz J, Dahut WL, Figg WD: Plasma protein binding of the investigational anticancer agent 2-methoxyestradiol. Anticancer Drugs. 2006 Sep;17(8):977-83. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/16940808 # Lakhani NJ, Sarkar MA, Venitz J, Figg WD: 2-Methoxyestradiol, a promising anticancer agent. Pharmacotherapy. 2003 Feb;23(2):165-72. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/12587805 (en)
http://linked.open...gy/drugbank/group
  • investigational (en)
http://linked.open...ugbank/indication
  • For the treatment of breast cancer and inflammatory diseases such as rheumatoid arthritis. (en)
sameAs
Title
  • 2-Methoxyestradiol (en)
adms:identifier
http://linked.open...mechanismOfAction
  • 2-Methoxyestradiol is an angiogenesis inhibitor, and has been shown to attack both tumor cells and their blood supply in preclinical testing. 2-methoxyestradiol is a naturally occurring estrogen metabolite but has no undesired estrogenic activity. (en)
http://linked.open.../drugbank/synonym
  • 2-Hydroxyestradiol 2-methyl ether (en)
  • 2-Hydroxyestradol 2-methyl ether (en)
  • 2-MeOE2 (en)
  • 2-Methoxyestradiol-17beta (en)
  • 2-methoxy-17beta-estradiol (en)
  • 2-methoxyestra-1(10),2,4-triene-3,17-diol (en)
  • 2ME2 (en)
  • ESM (en)
http://linked.open...nk/proteinBinding
  • 2ME2 was found to bind in decreasing order to plasma>albumin>alpha1-acid glycoprotein>sex-hormone-binding globulin. Plasma concentration-time profiles of total 2ME2 and unbound 2ME2 concentrations in a patient with cancer receiving 2ME2 as a single oral dose were parallel to each other. Thus, indicating that plasma protein binding is not an important consideration in pharmacokinetic monitoring of 2ME2. (en)
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http://linked.open.../affectedOrganism
  • Humans and other mammals (en)
http://linked.open...casRegistryNumber
  • 362-07-2 (en)
http://linked.open...drugbank/category
  • (en)
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