About: Molindone

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About: Molindone Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	An indole derivative effective in schizophrenia and other psychoses and possibly useful in the treatment of the aggressive type of undersocialized conduct disorder. Molindone has much lower affinity for D2 receptors than most antipsychotic agents and has a relatively low affinity for D1 receptors. It has only low to moderate affinity for cholinergic and alpha-adrenergic receptors. Some electrophysiologic data from animals indicate that molindone has certain characteristics that resemble those of clozapine. (From AMA Drug Evaluations Annual, 1994, p283) (en)
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...ugbank/indication	Molindone is used for the management of the manifestations of psychotic disorders. (en)
sameAs	Molindone
Title	Molindone (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB01618/identifier/bindingdb/50130290 http://linked.opendata.cz/resource/drugbank/drug/DB01618/identifier/chemspider/22342 http://linked.opendata.cz/resource/drugbank/drug/DB01618/identifier/drugbank/DB01618 http://linked.opendata.cz/resource/drugbank/drug/DB01618/identifier/guide-to-pharmacology/207 http://linked.opendata.cz/resource/drugbank/drug/DB01618/identifier/iuphar/207 http://linked.opendata.cz/resource/drugbank/drug/DB01618/identifier/kegg-compound/C07230 http://linked.opendata.cz/resource/drugbank/drug/DB01618/identifier/national-drug-code-directory/63481-072-70 http://linked.opendata.cz/resource/drugbank/drug/DB01618/identifier/pubchem-compound/23897 http://linked.opendata.cz/resource/drugbank/drug/DB01618/identifier/pubchem-substance/46504744 http://linked.opendata.cz/resource/drugbank/drug/DB01618/identifier/pharmgkb/PA164746756 http://linked.opendata.cz/resource/drugbank/drug/DB01618/identifier/wikipedia/Molindone
http://linked.open...mechanismOfAction	The exact mechanism has not been established, however, based on electroencephalogram (EEG) studies, molindone is thought to act by occupying (antagonizing) dopamine (D2) receptor sites in the reticular limbic systems in the brain, thus decreasing dopamine activity. Decreased dopamine activity results in decreased physiological effects normally induced by excessive dopamine stimulation, such as those typically seen in manifestations of psychotic disorders. (en)
http://linked.open...drugbank/packager	Endo Pharmaceuticals Inc. Altana inc Bristol-Myers Squibb Co.
http://linked.open...outeOfElimination	Human metabolic studies show molindone to be rapidly absorbed and metabolized when given orally. There are 36 recognized metabolites with less than 2-3% unmetabolized molindone being excreted in urine and feces. (en)
http://linked.open.../drugbank/synonym	Molindone (en) Moban (en) (+-)-molindone (en) Molindona (en) Molindonum (en) SID26755691 (en) SID50111112 (en) SID90341242 (en)
http://linked.open...ynthesisReference	"DrugSyn.org":http://www.drugsyn.org/Molindone.htm (en)
foaf:page	http://www.drugs.com/cdi/molindone.html http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/mob1614.shtml http://www.rxlist.com/cgi/generic/molindone.htm
http://linked.open...ugbank/IUPAC-Name	http://linked.opendata.cz/resource/drugbank/property/271B5CBA-363D-11E5-9242-09173F13E4C5
http://linked.open...gy/drugbank/InChI	http://linked.opendata.cz/resource/drugbank/property/271B5CC0-363D-11E5-9242-09173F13E4C5
http://linked.open...Molecular-Formula	http://linked.opendata.cz/resource/drugbank/property/271B5CBF-363D-11E5-9242-09173F13E4C5
http://linked.open.../Molecular-Weight	http://linked.opendata.cz/resource/drugbank/property/271B5CBC-363D-11E5-9242-09173F13E4C5
http://linked.open...noisotopic-Weight	http://linked.opendata.cz/resource/drugbank/property/271B5CBD-363D-11E5-9242-09173F13E4C5
http://linked.open...y/drugbank/SMILES	http://linked.opendata.cz/resource/drugbank/property/271B5CBE-363D-11E5-9242-09173F13E4C5
http://linked.open.../Water-Solubility	http://linked.opendata.cz/resource/drugbank/property/271B5CB8-363D-11E5-9242-09173F13E4C5
http://linked.open...ogy/drugbank/logP	http://linked.opendata.cz/resource/drugbank/property/271B5CB6-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/property/271B5CB9-363D-11E5-9242-09173F13E4C5
http://linked.open...ogy/drugbank/logS	http://linked.opendata.cz/resource/drugbank/property/271B5CB7-363D-11E5-9242-09173F13E4C5
http://linked.open...l/drug/hasATCCode	Molindone
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http://linked.open...atable-Bond-Count	http://linked.opendata.cz/resource/drugbank/property/271B5CC5-363D-11E5-9242-09173F13E4C5
http://linked.open...ugbank/absorption	Rapidly absorbed from the gastrointestinal tract following oral administration. (en)
http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	7416-34-4 (en)
http://linked.open...drugbank/category	(en)
http://linked.open...gbank/containedIn	Moban 5 mg tablet Betapace af 80 mg tablet Amoxil 250 mg/5ml Suspension 100ml Bottle Amoxil 250 mg/5ml Suspension 150ml Bottle
http://linked.open...k/Bioavailability	http://linked.opendata.cz/resource/drugbank/property/271B5CCC-363D-11E5-9242-09173F13E4C5
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http://linked.open...siological-Charge	http://linked.opendata.cz/resource/drugbank/property/271B5CCA-363D-11E5-9242-09173F13E4C5
http://linked.open...bank/Rule-of-Five	http://linked.opendata.cz/resource/drugbank/property/271B5CCD-363D-11E5-9242-09173F13E4C5
http://linked.open...tional-IUPAC-Name	http://linked.opendata.cz/resource/drugbank/property/271B5CBB-363D-11E5-9242-09173F13E4C5
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