About: Nitrazepam     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type
http://linked.open...gbank/description
  • A benzodiazepine derivative used as an anticonvulsant and hypnotic. (en)
http://linked.open...generalReferences
  • # Rickels K: The clinical use of hypnotics: indications for use and the need for a variety of hypnotics. Acta Psychiatr Scand Suppl. 1986;332:132-41. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/2883820 # Robertson MD, Drummer OH: Postmortem drug metabolism by bacteria. J Forensic Sci. 1995 May;40(3):382-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/7782744 # Oelschlager H: [Chemical and pharmacologic aspects of benzodiazepines] Schweiz Rundsch Med Prax. 1989 Jul 4;78(27-28):766-72. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/2570451 # Podhorna J, Krsiak M: Behavioural effects of a benzodiazepine receptor partial agonist, Ro 19-8022, in the social conflict test in mice. Behav Pharmacol. 2000 Apr;11(2):143-51. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10877119 # Nowakowska E, Chodera A: Studies on the involvement of opioid mechanism in the locomotor effects of benzodiazepines in rats. Pharmacol Biochem Behav. 1991 Feb;38(2):265-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/1676167 (en)
http://linked.open...gy/drugbank/group
  • approved (en)
http://linked.open...drugbank/halfLife
  • 15-38 hours (mean elimination half life 26 hours). (en)
http://linked.open...ugbank/indication
  • Used to treat short-term sleeping problems (insomnia), such as difficulty falling asleep, frequent awakenings during the night, and early-morning awakening. (en)
sameAs
Title
  • Nitrazepam (en)
adms:identifier
http://linked.open...mechanismOfAction
  • Nitrazepam belongs to a group of medicines called benzodiazepines. It acts on benzodiazepine receptors in the brain which are associated with the GABA receptors causing an enhanced binding of GABA (gamma amino butyric acid) to GABAA receptors. GABA is a major inhibitory neurotransmitter in the brain, involved in inducing sleepiness, muscular relaxation and control of anxiety and fits, and slows down the central nervous system. The anticonvulsant properties of nitrazepam and other benzodiazepines may be in part or entirely due to binding to voltage-dependent sodium channels rather than benzodiazepine receptors. Sustained repetitive firing seems to be limited by benzodiazepines effect of slowing recovery of sodium channels from inactivation. (en)
http://linked.open.../drugbank/synonym
  • Apodorm (en)
  • Benzalin (en)
  • Calsmin (en)
  • Eatan (en)
  • Eunoctin (en)
  • Gerson (en)
  • Hipnax (en)
  • Hipsal (en)
  • Ibrovek (en)
  • Imeson (en)
  • Imesont (en)
  • Mogadon (en)
  • Nelbon (en)
  • Nelmat (en)
  • Neozepam (en)
  • Neuchlonic (en)
  • Nitrados (en)
  • Paxisyn (en)
  • Pelson (en)
  • Persopit (en)
  • Radedorm (en)
  • Relact (en)
  • Remnos (en)
  • Somitran (en)
  • Sonebon (en)
  • Sonnolin (en)
  • Surem (en)
  • Trazenin (en)
  • Unisomnia (en)
  • 7-Nitro-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one (en)
  • 7-Nitro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one (en)
  • 1,3-dihydro-7-Nitro-5-phenyl-2H-1,4-benzodiazepin-2-one (en)
  • Atempol (en)
  • N-Desmethylnimetazepam (en)
  • Nitrazepamum (en)
  • Ro 4-5360 (en)
  • Ro 5-3059 (en)
  • 2,3-dihydro-7-Nitro-5-phenyl-1H-1,4-benzodiazepin-2-one (en)
http://linked.open...drugbank/toxicity
  • Nitrazepam is a drug which is very frequently involved in drug intoxication, including overdose. Nitrazepam overdose may result in stereotypical symptoms of benzodiazepine overdose including intoxication, impaired balance, slurred speech. In cases of severe overdose this may progress to a comatose state with the possibility of death. (en)
http://linked.open.../drug/hasAHFSCode
http://linked.open...k/foodInteraction
  • Avoid alcohol. (en)
  • Take with food. (en)
  • Avoid excessive quantities of coffee or tea (Caffeine). (en)
http://linked.open...ugbank/IUPAC-Name
http://linked.open...gy/drugbank/InChI
http://linked.open...Molecular-Formula
http://linked.open.../Molecular-Weight
http://linked.open...noisotopic-Weight
http://linked.open...y/drugbank/SMILES
http://linked.open.../Water-Solubility
http://linked.open...ogy/drugbank/logP
http://linked.open...ogy/drugbank/logS
http://linked.open...l/drug/hasATCCode
http://linked.open...nd-Acceptor-Count
http://linked.open...-Bond-Donor-Count
http://linked.open...drugbank/InChIKey
http://linked.open...urface-Area--PSA-
http://linked.open...nk/Polarizability
http://linked.open...bank/Refractivity
http://linked.open...atable-Bond-Count
http://linked.open...ugbank/absorption
  • Bioavailability is 53-94% following oral administration. (en)
http://linked.open.../affectedOrganism
  • Humans and other mammals (en)
http://linked.open...casRegistryNumber
  • 146-22-5 (en)
http://linked.open...drugbank/category
  • (en)
http://linked.open...gbank/containedIn
http://linked.open...k/Bioavailability
http://linked.open...bank/Ghose-Filter
http://linked.open...nk/MDDR-Like-Rule
http://linked.open...ank/Melting-Point
http://linked.open...k/Number-of-Rings
http://linked.open...siological-Charge
http://linked.open...bank/Rule-of-Five
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