About: Calusterone     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
http://linked.open...gbank/description
  • A 17-alkylated orally active androgenic steroid. A Schedule IV drug in Canada. (en)
http://linked.open...generalReferences
  • # Meli RJ, Ros PR: MR appearance of intra-abdominal metastatic melanoma. Magn Reson Imaging. 1992;10(4):705-8. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/1501542 (en)
http://linked.open...gy/drugbank/group
  • experimental (en)
  • illicit (en)
http://linked.open...ugbank/indication
  • An anabolic steroid which can theoretically aid in restauration and buildup of certain tissues, especially muscle. It is similar to synthetic testosterone and is still in early investigation. It was also investigated for use as a treatment for metastatic breast cancer. (en)
sameAs
Title
  • Calusterone (en)
adms:identifier
http://linked.open...mechanismOfAction
  • The effects of calusterone in humans most likely occur by way of two main mechanisms: by activation of the androgen receptor, and by conversion to estradiol and activation of certain estrogen receptors. Using testosterone as the prime example, free testosterone (T) is transported into the cytoplasm of target tissue cells, where it can bind to the androgen receptor, or can be reduced to 5α-dihydrotestosterone (DHT) by the cytoplasmic enzyme 5α-reductase. DHT binds to the same androgen receptor even more strongly than T, so that its androgenic potency is about 2.5 times that of T. The T-receptor or DHT-receptor complex undergoes a structural change that allows it to move into the cell nucleus and bind directly to specific nucleotide sequences of the chromosomal DNA. The areas of binding are called hormone response elements (HREs), and influence transcriptional activity of certain genes, producing the androgen effects. (en)
http://linked.open.../drugbank/synonym
  • 17beta-Hydroxy-7beta,17-dimethylandrost-4-en-3-one (en)
  • 7-beta,17-Dimethyltestosterone (en)
  • 7-beta,17-alpha-Dimethyl testosterone (en)
  • 7beta,17-Dimethyltestosterone (en)
  • 7beta,17alpha-Dimethyltestosterone (en)
  • CLS (en)
  • Calusteron (en)
  • 17beta-Hydroxy-7beta,17alpha-dimethylandrost-4-ene-3-one (en)
  • 17-beta-Hydroxy-7-beta,17-alpha-dimethylandrost-4-ene-3-one (en)
  • Calusterona (en)
  • Calusteronum (en)
http://linked.open...ugbank/IUPAC-Name
http://linked.open...gy/drugbank/InChI
http://linked.open...Molecular-Formula
http://linked.open.../Molecular-Weight
http://linked.open...noisotopic-Weight
http://linked.open...y/drugbank/SMILES
http://linked.open.../Water-Solubility
http://linked.open...ogy/drugbank/logP
http://linked.open...ogy/drugbank/logS
http://linked.open...nd-Acceptor-Count
http://linked.open...-Bond-Donor-Count
http://linked.open...drugbank/InChIKey
http://linked.open...urface-Area--PSA-
http://linked.open...nk/Polarizability
http://linked.open...bank/Refractivity
http://linked.open...atable-Bond-Count
http://linked.open.../affectedOrganism
  • Humans and other mammals (en)
http://linked.open...casRegistryNumber
  • 17021-26-0 (en)
http://linked.open...k/Bioavailability
http://linked.open...bank/Ghose-Filter
http://linked.open...nk/MDDR-Like-Rule
http://linked.open...ank/Melting-Point
http://linked.open...k/Number-of-Rings
http://linked.open...siological-Charge
http://linked.open...bank/Rule-of-Five
http://linked.open...tional-IUPAC-Name
http://linked.open...strongest-acidic-
http://linked.open...-strongest-basic-
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