About: Cloxazolam     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type
http://linked.open...gbank/description
  • Cloxazolam is a benzodiazepine with anxiolytic, sedative/hypnotic, muscle relaxant, and antiepileptic effects. [3] It is marketed in the Argentina, Australia, Portugal, Belgium, Switzerland, Luxembourg, Germany, Taiwan and Japan -- mainly for anti-anxiety. The usual dose of cloxazolam in adults is 3-12mg/day for anti-anxiety. [3] Although less commonly noted, it has also been reported as clinically effective in the treatment of depression, schizophrenia, and neurosis. [4] As well, it has also been studied in Japan in doses of 15-30mg/day as an adjunct in the treatment of intractable epilepsy, for which it has demonstrated effectiveness. [3] (en)
http://linked.open...generalReferences
  • 1. Ansseau, Marc, and Remy von Frenckell. "Controlled comparison of two anxiolytic benzodiazepines, cloxazolam and bromazepam." Neuropsychobiology 24.1 (1990): 25-29 2. Boucsein, W., and G. Wendt-Suhl. "Psychological and physiological effects of cloxazolam and diazepam under anxiety-evoking and control conditions on healthy subjects (author's transl)]." Pharmacopsychiatria 15.2 (1982): 48. 3. Ito, Masatoshi, et al. "Cloxazolam treatment for patients with intractable epilepsy." Pediatric neurology 30.2 (2004): 111-114. 4. Murata, Hisashi, et al. "Metabolism of Cloxazolam. I. Distribution, Excretion and Biotransformation in Rats and Mice." Chemical & pharmaceutical bulletin 21.2 (1973): 404-414. 5. Oliveira‐Silva, Diogo, et al. "Quantification of chlordesmethyldiazepam by liquid chromatography–tandem mass spectrometry: application to a cloxazolam bioequivalence study." Biomedical Chromatography 23.12 (2009): 1266-1275. (en)
http://linked.open...gy/drugbank/group
  • approved (en)
  • investigational (en)
http://linked.open...drugbank/halfLife
  • 65 hours (en)
http://linked.open...ugbank/indication
  • Used primarily as an anti-anxiety agent. Typically used short term, and may be given as a single dose of up to 100mcg/kg to reduce anxiety and tension experienced prior to surgery. (en)
sameAs
Title
  • Cloxazolam (en)
adms:identifier
http://linked.open...mechanismOfAction
  • Cloxazolam is a long acting benzodiazepine. It acts as a prodrug, with pharmacologically active metabolites, which bind to to the GABAa receptor, which other benzodiazepines bind to, to illicit a physiological response. [wiki] (en)
http://linked.open...outeOfElimination
  • Renal elimination. (en)
http://linked.open.../drugbank/synonym
  • Cloxazolazepam (en)
  • MT 14-411 (en)
  • Sepazon (en)
http://linked.open...drugbank/toxicity
  • Drowsiness and ataxia are dose related. Central nervous system toxicity may result in respiratory depression and loss of consciousness. As such, pre-existing central nervous system depression and severe hepatic impairment are two particular contraindications for use. (en)
http://linked.open...k/foodInteraction
  • Alcohol used in combination may enhance sedation or cause potentially fatal respiratory/cardiovascular depression. (en)
http://linked.open...ynthesisReference
  • Tachikawa, R., Takagi, H., Kamioka, T., Fukunaga, M., Kawano, Y. and Miyadera, T.; US. Patents 3,696,094; October 3,1972; and 3,772,371; November 13, 1973; both assigned to Sankyo Company Limited, Japan. (en)
foaf:page
http://linked.open...ugbank/IUPAC-Name
http://linked.open...gy/drugbank/InChI
http://linked.open...Molecular-Formula
http://linked.open.../Molecular-Weight
http://linked.open...noisotopic-Weight
http://linked.open...y/drugbank/SMILES
http://linked.open.../Water-Solubility
http://linked.open...ogy/drugbank/logP
http://linked.open...ogy/drugbank/logS
http://linked.open...l/drug/hasATCCode
http://linked.open...nd-Acceptor-Count
http://linked.open...-Bond-Donor-Count
http://linked.open...drugbank/InChIKey
http://linked.open...urface-Area--PSA-
http://linked.open...nk/Polarizability
http://linked.open...bank/Refractivity
http://linked.open...atable-Bond-Count
http://linked.open...casRegistryNumber
  • 24166-13-0 (en)
http://linked.open...drugbank/category
  • (en)
http://linked.open...k/Bioavailability
http://linked.open...bank/Ghose-Filter
http://linked.open...nk/MDDR-Like-Rule
http://linked.open...ank/Melting-Point
http://linked.open...k/Number-of-Rings
http://linked.open...siological-Charge
http://linked.open...bank/Rule-of-Five
http://linked.open...tional-IUPAC-Name
http://linked.open...strongest-acidic-
http://linked.open...-strongest-basic-
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