About: 3,4-Methylenedioxymethamphetamine

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	An N-substituted amphetamine analog. It is a widely abused drug classified as a hallucinogen and causes marked, long-lasting changes in brain serotonergic systems. It is commonly referred to as MDMA or ecstasy. [PubChem] (en)
http://linked.open...generalReferences	# Freudenmann RW, Oxler F, Bernschneider-Reif S: The origin of MDMA (ecstasy) revisited: the true story reconstructed from the original documents. Addiction. 2006 Sep;101(9):1241-5. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/16911722 # Jayanthi LD, Ramamoorthy S: Regulation of monoamine transporters: influence of psychostimulants and therapeutic antidepressants. AAPS J. 2005 Oct 27;7(3):E728-38. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/16353949 # Verrico CD, Miller GM, Madras BK: MDMA (Ecstasy) and human dopamine, norepinephrine, and serotonin transporters: implications for MDMA-induced neurotoxicity and treatment. Psychopharmacology (Berl). 2007 Jan;189(4):489-503. Epub 2005 Oct 12. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/16220332 (en)
http://linked.open...gy/drugbank/group	experimental (en) illicit (en)
http://linked.open...drugbank/halfLife	6–10 (though duration of effects is typically actually 3–5 hours) (en)
http://linked.open...ugbank/indication	Clinical trials are now testing the therapeutic potential of MDMA for post-traumatic stress disorder (PTSD) and anxiety associated with terminal cancer. MDMA is one of the four most widely used illicit drugs in the U.S. (en)
sameAs	3,4-Methylenedioxymethamphetamine
Title	3,4-Methylenedioxymethamphetamine (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB01454/identifier/chebi/1391 http://linked.opendata.cz/resource/drugbank/drug/DB01454/identifier/chemspider/1556 http://linked.opendata.cz/resource/drugbank/drug/DB01454/identifier/drugbank/DB01454 http://linked.opendata.cz/resource/drugbank/drug/DB01454/identifier/kegg-compound/C07577 http://linked.opendata.cz/resource/drugbank/drug/DB01454/identifier/pharmgkb/PA131887008 http://linked.opendata.cz/resource/drugbank/drug/DB01454/identifier/pubchem-compound/1615 http://linked.opendata.cz/resource/drugbank/drug/DB01454/identifier/pubchem-substance/46506404 http://linked.opendata.cz/resource/drugbank/drug/DB01454/identifier/wikipedia/3%2C4-Methylenedioxymethamphetamine
http://linked.open...mechanismOfAction	It enters neurons via carriage by the monoamine transporters. Once inside, MDMA inhibits the vesicular monoamine transporter, which results in increased concentrations of serotonin, norepinephrine, and dopamine into the cytoplasm, and induces their release by reversing their respective transporters through a process known as phosphorylation. It also acts as a weak 5-HT1 and 5-HT2 receptor agonist. MDMA's unusual entactogenic effects have been hypothesized to be, at least partly, the result of indirect oxytocin secretion via activation of the serotonin system. Oxytocin is a hormone released following events like hugging, orgasm, and childbirth, and is thought to facilitate bonding and the establishment of trust. Based on studies in rats, MDMA is believed to cause the release of oxytocin, at least in part, by both directly and indirectly agonizing the serotonin 5-HT1A receptor. (en)
http://linked.open...outeOfElimination	renal (en)
http://linked.open.../drugbank/synonym	Ecstasy (en) MDMA (en)
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http://linked.open...casRegistryNumber	42542-10-9 (en)
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