About: Glycodiazine

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About: Glycodiazine Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	Glycodiazine is used with diet to lower blood glucose by increasing the secretion of insulin from pancreas and increasing the sensitivity of peripheral tissues to insulin. The mechanism of action of glycodiazine in lowering blood glucose appears to be dependent on stimulating the release of insulin from functioning pancreatic beta cells, and increasing sensitivity of peripheral tissues to insulin. Glycodiazine likely binds to ATP-sensitive potassium channel receptors on the pancreatic cell surface, reducing potassium conductance and causing depolarization of the membrane. Membrane depolarization stimulates calcium ion influx through voltage-sensitive calcium channels. This increase in intracellular calcium ion concentration induces the secretion of insulin. It is used for the concomitant use with insulin for the treatment of noninsulin-dependent (type 2) diabetes mellitus. (en)
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...drugbank/halfLife	4 hours. (en)
http://linked.open...ugbank/indication	Glycodiazine is used concomitantly with insulin for the treatment of noninsulin-dependent (type 2) diabetes mellitus. (en)
sameAs	Glycodiazine
Title	Glycodiazine (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB01382/identifier/chemspider/9190 http://linked.opendata.cz/resource/drugbank/drug/DB01382/identifier/drugbank/DB01382 http://linked.opendata.cz/resource/drugbank/drug/DB01382/identifier/pubchem-compound/9565 http://linked.opendata.cz/resource/drugbank/drug/DB01382/identifier/pubchem-substance/46507076 http://linked.opendata.cz/resource/drugbank/drug/DB01382/identifier/pharmgkb/PA164748839
http://linked.open...mechanismOfAction	The mechanism of action of glycodiazine in lowering blood glucose appears to be dependent on stimulating the release of insulin from functioning pancreatic beta cells, and increasing sensitivity of peripheral tissues to insulin. Glycodiazine likely binds to ATP-sensitive potassium channel receptors on the pancreatic cell surface, reducing potassium conductance and causing depolarization of the membrane. Membrane depolarization stimulates calcium ion influx through voltage-sensitive calcium channels. The rise in intracellular calcium leads to increased fusion of insulin granulae with the cell membrane, and therefore increased secretion of (pro)insulin. (en)
http://linked.open.../drugbank/synonym	Glymidine (en) Glidiazine (en)
http://linked.open...drugbank/toxicity	Severe hypoglycemic reactions with coma, seizure, or other neurological impairment. (en)
http://linked.open...nk/proteinBinding	90% bound to plasma proteins. (en)
http://linked.open...ynthesisReference	U.S. Patent 3,275,635. (en)
http://linked.open...ugbank/IUPAC-Name	http://linked.opendata.cz/resource/drugbank/property/271B442C-363D-11E5-9242-09173F13E4C5
http://linked.open...gy/drugbank/InChI	http://linked.opendata.cz/resource/drugbank/property/271B4432-363D-11E5-9242-09173F13E4C5
http://linked.open...Molecular-Formula	http://linked.opendata.cz/resource/drugbank/property/271B4431-363D-11E5-9242-09173F13E4C5
http://linked.open.../Molecular-Weight	http://linked.opendata.cz/resource/drugbank/property/271B442E-363D-11E5-9242-09173F13E4C5
http://linked.open...noisotopic-Weight	http://linked.opendata.cz/resource/drugbank/property/271B442F-363D-11E5-9242-09173F13E4C5
http://linked.open...y/drugbank/SMILES	http://linked.opendata.cz/resource/drugbank/property/271B4430-363D-11E5-9242-09173F13E4C5
http://linked.open.../Water-Solubility	http://linked.opendata.cz/resource/drugbank/property/271B442A-363D-11E5-9242-09173F13E4C5
http://linked.open...ogy/drugbank/logP	http://linked.opendata.cz/resource/drugbank/property/271B4428-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/property/271B442B-363D-11E5-9242-09173F13E4C5
http://linked.open...ogy/drugbank/logS	http://linked.opendata.cz/resource/drugbank/property/271B4429-363D-11E5-9242-09173F13E4C5
http://linked.open...l/drug/hasATCCode	Glymidine
http://linked.open...nd-Acceptor-Count	http://linked.opendata.cz/resource/drugbank/property/271B4438-363D-11E5-9242-09173F13E4C5
http://linked.open...-Bond-Donor-Count	http://linked.opendata.cz/resource/drugbank/property/271B4439-363D-11E5-9242-09173F13E4C5
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http://linked.open...urface-Area--PSA-	http://linked.opendata.cz/resource/drugbank/property/271B4434-363D-11E5-9242-09173F13E4C5
http://linked.open...nk/Polarizability	http://linked.opendata.cz/resource/drugbank/property/271B4436-363D-11E5-9242-09173F13E4C5
http://linked.open...bank/Refractivity	http://linked.opendata.cz/resource/drugbank/property/271B4435-363D-11E5-9242-09173F13E4C5
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http://linked.open...ugbank/absorption	Rapidly and completely absorbed following oral administration. (en)
http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	339-44-6 (en)
http://linked.open...k/Bioavailability	http://linked.opendata.cz/resource/drugbank/property/271B443E-363D-11E5-9242-09173F13E4C5
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http://linked.open...siological-Charge	http://linked.opendata.cz/resource/drugbank/property/271B443C-363D-11E5-9242-09173F13E4C5
http://linked.open...bank/Rule-of-Five	http://linked.opendata.cz/resource/drugbank/property/271B443F-363D-11E5-9242-09173F13E4C5
http://linked.open...tional-IUPAC-Name	http://linked.opendata.cz/resource/drugbank/property/271B442D-363D-11E5-9242-09173F13E4C5
http://linked.open...strongest-acidic-	http://linked.opendata.cz/resource/drugbank/property/271B443A-363D-11E5-9242-09173F13E4C5
http://linked.open...-strongest-basic-	http://linked.opendata.cz/resource/drugbank/property/271B443B-363D-11E5-9242-09173F13E4C5

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