About: Amobarbital

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

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http://linked.open...gbank/description	A barbiturate with hypnotic and sedative properties (but not antianxiety). Adverse effects are mainly a consequence of dose-related CNS depression and the risk of dependence with continued use is high. (From Martindale, The Extra Pharmacopoeia, 30th ed, p565) (en)
http://linked.open...generalReferences	# Kim HS, Wan X, Mathers DA, Puil E: Selective GABA-receptor actions of amobarbital on thalamic neurons. Br J Pharmacol. 2004 Oct;143(4):485-94. Epub 2004 Sep 20. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/15381635 # Maynert EW: The alcoholic metabolites of pentobarbital and amobarbital in man. J Pharmacol Exp Ther. 1965 Oct;150(1):118-21. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/5855308 # Tang BK, Kalow W, Grey AA: Amobarbital metabolism in man: N-glucoside formation. Res Commun Chem Pathol Pharmacol. 1978 Jul;21(1):45-53. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/684279 # Soine PJ, Soine WH: High-performance liquid chromatographic determination of the diastereomers of 1-(beta-D-glucopyranosyl)amobarbital in urine. J Chromatogr. 1987 Nov 27;422:309-14. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/3437019 # McCall WV: The addition of intravenous caffeine during an amobarbital interview. J Psychiatry Neurosci. 1992 Nov;17(5):195-7. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/1489761 (en)
http://linked.open...gy/drugbank/group	approved (en) illicit (en)
sameAs	Amobarbital
Title	Amobarbital (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB01351/identifier/chebi/2673 http://linked.opendata.cz/resource/drugbank/drug/DB01351/identifier/chemspider/2079 http://linked.opendata.cz/resource/drugbank/drug/DB01351/identifier/drugbank/DB01351 http://linked.opendata.cz/resource/drugbank/drug/DB01351/identifier/kegg-compound/C07536 http://linked.opendata.cz/resource/drugbank/drug/DB01351/identifier/kegg-drug/D00555 http://linked.opendata.cz/resource/drugbank/drug/DB01351/identifier/pubchem-compound/2164 http://linked.opendata.cz/resource/drugbank/drug/DB01351/identifier/pubchem-substance/46508165 http://linked.opendata.cz/resource/drugbank/drug/DB01351/identifier/pharmgkb/PA448401 http://linked.opendata.cz/resource/drugbank/drug/DB01351/identifier/wikipedia/Amobarbital
http://linked.open...mechanismOfAction	Amobarbital (like all barbiturates) works by binding to the GABAA receptor at either the alpha or the beta sub unit. These are binding sites that are distinct from GABA itself and also distinct from the benzodiazepine binding site. Like benzodiazepines, barbiturates potentiate the effect of GABA at this receptor. This GABAA receptor binding decreases input resistance, depresses burst and tonic firing, especially in ventrobasal and intralaminar neurons, while at the same time increasing burst duration and mean conductance at individual chloride channels; this increases both the amplitude and decay time of inhibitory postsynaptic currents. In addition to this GABA-ergic effect, barbiturates also block the AMPA receptor, a subtype of glutamate receptor. Glutamate is the principal excitatory neurotransmitter in the mammalian CNS. Amobarbital also appears to bind neuronal nicotinic acetylcholine receptors. (en)
http://linked.open...drugbank/packager	AAIPharma Inc. Marathon Pharmaceuticals Ranbaxy Laboratories
http://linked.open.../drugbank/synonym	Amobarbital (en) Amylobarbitone (en) 5-Ethyl-5-(3-methylbutyl)-2,4,6(1H,3H,5H)-pyrimidinetrione (en) 5-Ethyl-5-(3-methylbutyl)barbituric acid (en) 5-Ethyl-5-isoamylbarbituric acid (en) 5-Ethyl-5-isopentylbarbituric acid (en) Amytal (en) Barbamil (en) Barbamyl (en)
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http://linked.open...casRegistryNumber	57-43-2 (en)
http://linked.open...gbank/containedIn	Amytal sodium 0.5 gram vial
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