About: Corticotropin

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	Corticotropin (ACTH or adrenocorticotropic hormone) is a polypeptide hormone produced and secreted by the pituitary gland. It is an important player in the hypothalamic-pituitary-adrenal axis. (en)
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...drugbank/halfLife	About 15 minutes following intravenous administration. (en)
http://linked.open...ugbank/indication	For use as a diagnostic agent in the screening of patients presumed to have adrenocortical insufficiency. (en)
sameAs	Corticotropin
Title	Corticotropin (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB01285/identifier/drugbank/DB01285 http://linked.opendata.cz/resource/drugbank/drug/DB01285/identifier/kegg-compound/C02017 http://linked.opendata.cz/resource/drugbank/drug/DB01285/identifier/kegg-drug/D00146 http://linked.opendata.cz/resource/drugbank/drug/DB01285/identifier/pharmgkb/PA449129 http://linked.opendata.cz/resource/drugbank/drug/DB01285/identifier/wikipedia/Adrenocorticotropic_hormone
http://linked.open...mechanismOfAction	As a diagnostic aid (adrenocortical function), corticotropin combines with a specific receptor on the adrenal cell plasma membrane. In patients with normal adrenocortical function, it stimulates the initial reaction involved in the synthesis of adrenal steroids (including cortisol, cortisone, weak androgenic substances, and a limited quantity of aldosterone) from cholesterol by increasing the quantity of cholesterol within the mitochondria. Corticotropin does not significantly increase serum cortisol concentrations in patients with primary adrenocortical insufficiency (Addison's disease). The mechanism of action of corticotropin in the treatment of infantile myoclonic seizures is unknown. (en)
http://linked.open...drugbank/packager	Major Pharmaceuticals Altana inc
http://linked.open.../drugbank/synonym	ACTH (en) Adrenocorticotropic hormone (en)
http://linked.open...ynthesisReference	Wylie W. Vale, Jr., Mary P. Stenzel-Poore, "Corticotropin-releasing factor overproducing transgenic mice." U.S. Patent US6023011, issued June, 1993. (en)
foaf:page	http://www.drugs.com/cdi/corticotropin-gel.html
http://linked.open...Molecular-Formula	http://linked.opendata.cz/resource/drugbank/property/271B6307-363D-11E5-9242-09173F13E4C5
http://linked.open.../Molecular-Weight	http://linked.opendata.cz/resource/drugbank/property/271B6306-363D-11E5-9242-09173F13E4C5
http://linked.open.../Water-Solubility	http://linked.opendata.cz/resource/drugbank/property/271B6305-363D-11E5-9242-09173F13E4C5
http://linked.open...l/drug/hasATCCode	Corticotropin
http://linked.open...ugbank/absorption	Corticotropin is rapidly absorbed following intramuscular administration; the repository dosage form is slowly absorbed over approximately 8 to 16 hours. (en)
http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	9002-60-2 (en)
http://linked.open...drugbank/category	(en)
http://linked.open...gbank/containedIn	Acthar hp gel 80 unit/ml vial

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