About: Cosyntropin

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	A synthetic peptide that is identical to the 24-amino acid segment at the N-terminal of adrenocorticotropic hormone. ACTH (1-24), a segment similar in all species, contains the biological activity that stimulates production of corticosteroids in the adrenal cortex. (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B62FC-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B62FD-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B62FE-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B62FF-363D-11E5-9242-09173F13E4C5
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...drugbank/halfLife	About 15 minutes following intravenous administration. (en)
http://linked.open...ugbank/indication	For use as a diagnostic agent in the screening of patients presumed to have adrenocortical insufficiency. (en)
sameAs	Cosyntropin
Title	Cosyntropin (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB01284/identifier/drugbank/DB01284 http://linked.opendata.cz/resource/drugbank/drug/DB01284/identifier/kegg-compound/C06926 http://linked.opendata.cz/resource/drugbank/drug/DB01284/identifier/kegg-drug/D00284 http://linked.opendata.cz/resource/drugbank/drug/DB01284/identifier/national-drug-code-directory/0781-3052-95 http://linked.opendata.cz/resource/drugbank/drug/DB01284/identifier/pharmgkb/PA164749052 http://linked.opendata.cz/resource/drugbank/drug/DB01284/identifier/wikipedia/Cosyntropin
http://linked.open...mechanismOfAction	Cosyntropin combines with a specific receptor in the adrenal cell plasma membrane and, in patients with normal adrenocortical function, stimulates the initial reaction involved in the synthesis of adrenal steroids (including cortisol, cortisone, weak androgenic substances, and a limited quantity of aldosterone) from cholesterol by increasing the quantity of the substrate within the mitochondria. Cosyntropin does not significantly increase plasma cortisol concentration in patients with primary or secondary adrenocortical insufficiency. (en)
http://linked.open...drugbank/packager	Amphastar Pharmaceuticals Diversified Healthcare Services Inc. Sandoz
http://linked.open.../drugbank/synonym	Tetracosactide (en) Cosyntropin (en) ATCH (1-24) (en) Adrenocorticotropic hormone 1-24 (en) Corticotropin-(1-24) (en) Corticotropin-(1-24) tetracosapeptide (en) SYSMEHFRWGKPVGKKRRPVKVYP (en) alpha(1-24)-Corticotrophin (en) beta(1-24)-Corticotrophin (en) SerTyrSerMetGluHisPheArgTrpGlyLysProValGlyLysLysArgArgProValLysValTyrPro (en)
http://linked.open.../drug/hasAHFSCode	http://linked.opendata.cz/resource/AHFS/68-28-00
foaf:page	http://www.drugs.com/cdi/cosyntropin.html http://www.rxlist.com/cgi/generic/cortrosyn.htm
http://linked.open...Molecular-Formula	http://linked.opendata.cz/resource/drugbank/property/271B6301-363D-11E5-9242-09173F13E4C5
http://linked.open.../Molecular-Weight	http://linked.opendata.cz/resource/drugbank/property/271B6300-363D-11E5-9242-09173F13E4C5
http://linked.open...l/drug/hasATCCode	Tetracosactide
http://linked.open...ugbank/absorption	Rapidly absorbed following intramuscular administration. (en)
http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	16960-16-0 (en)
http://linked.open...drugbank/category	(en)
http://linked.open...gbank/containedIn	Apo-Timop 0.25 % Solution Cosyntropin 0.25 mg/ml Cortrosyn 0.25 mg vial Novo-Naprox Sodium Ds 550 mg Tablet

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