About: Rifapentine

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About: Rifapentine Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	Rifapentine is an antibiotic drug used in the treatment of tuberculosis. It inhibits DNA-dependent RNA polymerase activity in susceptible cells. Specifically, it interacts with bacterial RNA polymerase but does not inhibit the mammalian enzyme. (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B5488-363D-11E5-9242-09173F13E4C5
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...ugbank/indication	For the treatment of pulmonary tuberculosis. (en)
sameAs	Rifapentine
Title	Rifapentine (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB01201/identifier/chebi/8861 http://linked.opendata.cz/resource/drugbank/drug/DB01201/identifier/chemspider/4883449 http://linked.opendata.cz/resource/drugbank/drug/DB01201/identifier/drugbank/DB01201 http://linked.opendata.cz/resource/drugbank/drug/DB01201/identifier/kegg-compound/C08059 http://linked.opendata.cz/resource/drugbank/drug/DB01201/identifier/kegg-drug/D00879 http://linked.opendata.cz/resource/drugbank/drug/DB01201/identifier/national-drug-code-directory/0088-2100-03 http://linked.opendata.cz/resource/drugbank/drug/DB01201/identifier/pdb/RPT http://linked.opendata.cz/resource/drugbank/drug/DB01201/identifier/pubchem-compound/6323497 http://linked.opendata.cz/resource/drugbank/drug/DB01201/identifier/pubchem-substance/46507322 http://linked.opendata.cz/resource/drugbank/drug/DB01201/identifier/pharmgkb/PA164783809 http://linked.opendata.cz/resource/drugbank/drug/DB01201/identifier/wikipedia/Rifapentine
http://linked.open...mechanismOfAction	Rifapentine has shown higher bacteriostatic and bactericidal activities especially against intracellular bacteria growing in human monocyte-derived macrophages. Rifapentine inhibits DNA-dependent RNA polymerase in susceptible strains of M. tuberculosis. Rifapentine acts via the inhibition of DNA-dependent RNA polymerase, leading to a suppression of RNA synthesis and cell death. (en)
http://linked.open...drugbank/packager	Gruppo Lepetit SPA Advanced Pharmaceutical Services Inc.
http://linked.open...outeOfElimination	Following a single 600 mg oral dose of radiolabeled rifapentine to healthy volunteers (n=4), 87% of the total 14C rifapentine was recovered in the urine (17%) and feces (70%). (en)
http://linked.open.../drugbank/synonym	Cyclopentylrifampicin (en) Priftin (tn) (en) 3-(((4-Cyclopentyl-1-piperazinyl)imino)methyl)rifamycin (en)
http://linked.open...umeOfDistribution	* 70.2 ± 9.1 L (en)
http://linked.open...nk/proteinBinding	97.7% (bound to plasma proteins) (en)
foaf:page	http://www.drugs.com/cdi/rifapentine.html http://www.rxlist.com/cgi/generic/priftin.htm
http://linked.open...ugbank/IUPAC-Name	http://linked.opendata.cz/resource/drugbank/property/271B548D-363D-11E5-9242-09173F13E4C5
http://linked.open...gy/drugbank/InChI	http://linked.opendata.cz/resource/drugbank/property/271B5493-363D-11E5-9242-09173F13E4C5
http://linked.open...Molecular-Formula	http://linked.opendata.cz/resource/drugbank/property/271B5492-363D-11E5-9242-09173F13E4C5
http://linked.open.../Molecular-Weight	http://linked.opendata.cz/resource/drugbank/property/271B548F-363D-11E5-9242-09173F13E4C5
http://linked.open...noisotopic-Weight	http://linked.opendata.cz/resource/drugbank/property/271B5490-363D-11E5-9242-09173F13E4C5
http://linked.open...y/drugbank/SMILES	http://linked.opendata.cz/resource/drugbank/property/271B5491-363D-11E5-9242-09173F13E4C5
http://linked.open.../Water-Solubility	http://linked.opendata.cz/resource/drugbank/property/271B548B-363D-11E5-9242-09173F13E4C5
http://linked.open...ogy/drugbank/logP	http://linked.opendata.cz/resource/drugbank/property/271B54A3-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/property/271B5489-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/property/271B548C-363D-11E5-9242-09173F13E4C5
http://linked.open...ogy/drugbank/logS	http://linked.opendata.cz/resource/drugbank/property/271B548A-363D-11E5-9242-09173F13E4C5
http://linked.open...l/drug/hasATCCode	Rifapentine
http://linked.open...nd-Acceptor-Count	http://linked.opendata.cz/resource/drugbank/property/271B5499-363D-11E5-9242-09173F13E4C5
http://linked.open...-Bond-Donor-Count	http://linked.opendata.cz/resource/drugbank/property/271B549A-363D-11E5-9242-09173F13E4C5
http://linked.open...drugbank/InChIKey	http://linked.opendata.cz/resource/drugbank/property/271B5494-363D-11E5-9242-09173F13E4C5
http://linked.open...urface-Area--PSA-	http://linked.opendata.cz/resource/drugbank/property/271B5495-363D-11E5-9242-09173F13E4C5
http://linked.open...nk/Polarizability	http://linked.opendata.cz/resource/drugbank/property/271B5497-363D-11E5-9242-09173F13E4C5
http://linked.open...bank/Refractivity	http://linked.opendata.cz/resource/drugbank/property/271B5496-363D-11E5-9242-09173F13E4C5
http://linked.open...atable-Bond-Count	http://linked.opendata.cz/resource/drugbank/property/271B5498-363D-11E5-9242-09173F13E4C5
http://linked.open...ugbank/absorption	Rapidly and well absorbed from the gastrointestinal tract. (en)
http://linked.open.../affectedOrganism	Mycobacterium (en) Mycobacterium tuberculosis (en)
http://linked.open...casRegistryNumber	61379-65-5 (en)
http://linked.open...drugbank/category	(en)
http://linked.open...rugbank/clearance	* Apparent Oral cl=2.51 +/- 0.14 L/h [Male tuberculosis patients who received 600 mg rifapentine in combination with isoniazid, pyrazinamide and ethambutol] * Apparent Oral cl=1.69 +/- 0.41 L/h [Female tuberculosis patients who received 600 mg rifapentine in combination with isoniazid, pyrazinamide and ethambutol] (en)
http://linked.open...gbank/containedIn	Locoid 0.1% lipocream
http://linked.open...k/Bioavailability	http://linked.opendata.cz/resource/drugbank/property/271B549F-363D-11E5-9242-09173F13E4C5
http://linked.open...bank/Ghose-Filter	http://linked.opendata.cz/resource/drugbank/property/271B54A1-363D-11E5-9242-09173F13E4C5
http://linked.open...nk/MDDR-Like-Rule	http://linked.opendata.cz/resource/drugbank/property/271B54A2-363D-11E5-9242-09173F13E4C5
http://linked.open...k/Number-of-Rings	http://linked.opendata.cz/resource/drugbank/property/271B549E-363D-11E5-9242-09173F13E4C5
http://linked.open...siological-Charge	http://linked.opendata.cz/resource/drugbank/property/271B549D-363D-11E5-9242-09173F13E4C5
http://linked.open...bank/Rule-of-Five	http://linked.opendata.cz/resource/drugbank/property/271B54A0-363D-11E5-9242-09173F13E4C5
http://linked.open...tional-IUPAC-Name	http://linked.opendata.cz/resource/drugbank/property/271B548E-363D-11E5-9242-09173F13E4C5
http://linked.open...strongest-acidic-	http://linked.opendata.cz/resource/drugbank/property/271B549B-363D-11E5-9242-09173F13E4C5
http://linked.open...-strongest-basic-	http://linked.opendata.cz/resource/drugbank/property/271B549C-363D-11E5-9242-09173F13E4C5

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