About: Anisindione

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	Anisindione is a synthetic anticoagulant and an indanedione derivative. It prevents the formation of active procoagulation factors II, VII, IX, and X, as well as the anticoagulant proteins C and S, in the liver by inhibiting the vitamin K-mediated gamma-carboxylation of precursor proteins. (en)
http://linked.open...generalReferences	# CONNELL WF, MAYER GA: Evaluation of anticoagulant therapy with anisindione (miradon). Can Med Assoc J. 1959 May 15;80(10):785-90. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/13652026 (en)
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...drugbank/halfLife	Not Known (en)
http://linked.open...ugbank/indication	For the prophylaxis and treatment of venous thrombosis and its extension, the treatment of atrial fibrillation with embolization, the prophylaxis and treatment of pulmonary embolism, and as an adjunct in the treatment of coronary occlusion. (en)
sameAs	Anisindione
Title	Anisindione (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB01125/identifier/chebi/133809 http://linked.opendata.cz/resource/drugbank/drug/DB01125/identifier/chemspider/2112 http://linked.opendata.cz/resource/drugbank/drug/DB01125/identifier/drugbank/DB01125 http://linked.opendata.cz/resource/drugbank/drug/DB01125/identifier/pubchem-compound/2197 http://linked.opendata.cz/resource/drugbank/drug/DB01125/identifier/pubchem-substance/46504660 http://linked.opendata.cz/resource/drugbank/drug/DB01125/identifier/pharmgkb/PA164746467 http://linked.opendata.cz/resource/drugbank/drug/DB01125/identifier/wikipedia/Anisindione
http://linked.open...mechanismOfAction	Like phenindione, to which it is related chemically, anisindione exercises its therapeutic action by reducing the prothrombin activity of the blood. Anisindione prevents the formation of active procoagulation factors II, VII, IX, and X, as well as the anticoagulant proteins C and S, in the liver by inhibiting the vitamin K–mediated gamma-carboxylation of precursor proteins. Anisindione has no direct thrombolytic effect and does not reverse ischemic tissue damage, although it may limit extension of existing thrombi and prevent secondary thromboembolic complications. (en)
http://linked.open.../drugbank/synonym	Anisin indandione (en) 2-(4-Methoxyphenyl)-1H-indene-1,3(2H)-dione (en) 2-(4-Methoxyphenyl)indan-1,3-dione (en) 2-(P-Methoxyphenyl)-1,3-indandione (en) 2-(P-Methoxyphenyl)indane-1,3-dione (en) 2-P-Anisyl-1,3-indandione (en) 2-Para-anisyl-1,3-indandione (en) Anisindiona (en) Anisindionum (en)
http://linked.open...drugbank/toxicity	An overdose is likely to cause abnormal bleeding, for which the symptoms include: bleeding from gums or nose, blood in urine or stools, excessive bleeding from minor cuts, patches of discoloration or bruises on the skin. (en)
http://linked.open...nk/proteinBinding	Not Known (en)
http://linked.open...ynthesisReference	Sperber, N.; US. Patent 2,899,358; August 11, 1959; assigned to Schering Corporation (en)
foaf:page	http://www.drugs.com/pdr/anisindione.html http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/mir1623.shtml http://www.rxlist.com/cgi/generic/miradon.htm
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http://linked.open...ugbank/absorption	Accumulation does not occur with repeated dosing. (en)
http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	117-37-3 (en)
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