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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

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http://linked.open...gbank/description
  • Butenafine hydrochloride is a synthetic benzylamine antifungal agent. Butenafine works by inhibiting the synthesis of sterols by inhibiting squalene epoxidase, an enzyme responsible for the creation of sterols needed in fungal cell membranes. (en)
http://linked.open...y/drugbank/dosage
http://linked.open...generalReferences
  • # McNeely W, Spencer CM: Butenafine. Drugs. 1998 Mar;55(3):405-12; discussion 413. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/9530545 # Singal A: Butenafine and superficial mycoses: current status. Expert Opin Drug Metab Toxicol. 2008 Jul;4(7):999-1005. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/18624686 # Gupta AK: Butenafine: an update of its use in superficial mycoses. Skin Therapy Lett. 2002 Sep;7(7):1-2, 5. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/12432425 # Mingeot-Leclercq MP, Gallet X, Flore C, Van Bambeke F, Peuvot J, Brasseur R: Experimental and conformational analyses of interactions between butenafine and lipids. Antimicrob Agents Chemother. 2001 Dec;45(12):3347-54. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/11709307 # Syed TA, Maibach HI: Butenafine hydrochloride: for the treatment of interdigital tinea pedis. Expert Opin Pharmacother. 2000 Mar;1(3):467-73. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/11249531 # Reyes BA, Beutner KR, Cullen SI, Rosen T, Shupack JL, Weinstein MB: Butenafine, a fungicidal benzylamine derivative, used once daily for the treatment of interdigital tinea pedis. Int J Dermatol. 1998 Jun;37(6):450-3. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/9646136 # Iwatani W, Arika T, Yamaguchi H: Two mechanisms of butenafine action in Candida albicans. Antimicrob Agents Chemother. 1993 Apr;37(4):785-8. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/8494375 (en)
http://linked.open...gy/drugbank/group
  • approved (en)
http://linked.open...drugbank/halfLife
  • Following topical application, a biphasic decline of plasma butenafine concentrations was observed with the half-lives estimated to be 35 hours initial and over 150 hours terminal. (en)
http://linked.open...ugbank/indication
  • For the topical treatment of the following dermatologic infections: tinea (pityriasis) versicolor due to <i>M. furfur</i>, interdigital tinea pedis (athlete&rsquo;s foot), tinea corporis (ringworm) and tinea cruris (jock itch) due to <i>E. floccosum</i>, <i>T. mentagrophytes</i>, <i>T. rubrum</i>, and <i>T. tonsurans</i>. (en)
sameAs
Title
  • Butenafine (en)
adms:identifier
http://linked.open...mechanismOfAction
  • Although the mechanism of action has not been fully established, it has been suggested that butenafine, like allylamines, interferes with sterol biosynthesis (especially ergosterol) by inhibiting squalene monooxygenase, an enzyme responsible for converting squalene to 2,3-oxydo squalene. As ergosterol is an essential component of the fungal cell membrane, inhibition of its synthesis results in increased cellular permeability causing leakage of cellular contents. Blockage of squalene monooxygenase also leads to a subsequent accumulation of squalene. When a high concentration of squalene is reached, it is thought to have an effect of directly kill fungal cells. (en)
http://linked.open...drugbank/packager
http://linked.open...y/drugbank/patent
http://linked.open.../drugbank/synonym
  • Butenafine (en)
  • (4-Tert-butyl-benzyl)-methyl-naphthalen-1-ylmethyl-amine (en)
  • Butenafina (en)
  • Butenafinum (en)
  • N-(P-Tert-butylbenzyl)-N-methyl-1-naphthalenemethylamine (en)
  • 4-Tert-butylbenzyl(methyl)(1-naphthalenemethyl)amine (en)
  • (4-Tert-butylphenyl)-N-methyl-N-(naphthalen-1-ylmethyl)methanamine (en)
http://linked.open...ogy/drugbank/salt
  • (en)
http://linked.open...ynthesisReference
  • "DrugSyn.org":http://www.drugsyn.org/Butenafine.htm (en)
foaf:page
http://linked.open...ugbank/IUPAC-Name
http://linked.open...gy/drugbank/InChI
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http://linked.open.../Molecular-Weight
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http://linked.open.../Water-Solubility
http://linked.open...ogy/drugbank/logP
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http://linked.open...l/drug/hasATCCode
http://linked.open...nd-Acceptor-Count
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http://linked.open...drugbank/InChIKey
http://linked.open...urface-Area--PSA-
http://linked.open...nk/Polarizability
http://linked.open...bank/Refractivity
http://linked.open...atable-Bond-Count
http://linked.open...ugbank/absorption
  • The total amount absorbed through the skin into the systemic circulation has not been quantified. (en)
http://linked.open.../affectedOrganism
  • Fungi (en)
http://linked.open...casRegistryNumber
  • 101828-21-1 (en)
http://linked.open...drugbank/category
  • (en)
http://linked.open...gbank/containedIn
http://linked.open...k/Bioavailability
http://linked.open...bank/Ghose-Filter
http://linked.open...nk/MDDR-Like-Rule
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http://linked.open...siological-Charge
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http://linked.open...tional-IUPAC-Name
http://linked.open...-strongest-basic-
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