About: Dihydrotachysterol

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	A vitamin D that can be regarded as a reduction product of vitamin D2. [PubChem] (en)
http://linked.open...generalReferences	# DeLuca HF: Overview of general physiologic features and functions of vitamin D. Am J Clin Nutr. 2004 Dec;80(6 Suppl):1689S-96S. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/15585789 # Bosch R, Thijssen JH, Duursma SA: Action and metabolism of dihydrotachysterol2. J Steroid Biochem. 1987;27(4-6):829-36. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/3320562 # Pierides AM: Pharmacology and therapeutic use of vitamin D and its analogues. Drugs. 1981 Apr;21(4):241-56. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/6262039 (en)
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...ugbank/indication	Used for the prevention and treatment of rickets or osteomalacia, and to manage hypocalcemia associated with hypoparathyroidism or pseudohypoparathyroidism. Also used for the treatment of vitamin D dependent rickets, rickets or osteomalacia secondary to long-term high dose anticonvulsant therapy, early renal osteodystrophy, osteoporosis (in conjunction with calcium), and hypophosphatemia associated with Fanconi syndrome (with treatment of acidosis). (en)
sameAs	Dihydrotachysterol
Title	Dihydrotachysterol (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB01070/identifier/chebi/4591 http://linked.opendata.cz/resource/drugbank/drug/DB01070/identifier/drugbank/DB01070 http://linked.opendata.cz/resource/drugbank/drug/DB01070/identifier/kegg-compound/C06957 http://linked.opendata.cz/resource/drugbank/drug/DB01070/identifier/kegg-drug/D00299 http://linked.opendata.cz/resource/drugbank/drug/DB01070/identifier/pharmgkb/PA164744345 http://linked.opendata.cz/resource/drugbank/drug/DB01070/identifier/wikipedia/Dihydrotachysterol
http://linked.open...mechanismOfAction	Once hydroxylated to 25-hydroxydihydrotachysterol, the modified drug binds to the vitamin D receptor. The bound form of the vitamin D receptor serves as a transcriptional regulator of bone matrix proteins, inducing the expression of osteocalcin and suppressing synthesis of type I collagen. Vitamin D (when bound to the vitamin D receptor)stimulates the expression of a number of proteins involved in transporting calcium from the lumen of the intestine, across the epithelial cells and into blood. This stimulates intestinal calcium absorption and increases renal phosphate excretion. These are functions that are normally carried out by the parathyroid hormone. (en)
http://linked.open...drugbank/packager	Baxter healthcare corp B braun medical inc Abbott laboratories pharmaceutical products div
http://linked.open.../drugbank/synonym	Dihydrotachysterol (en) Vitamin D4 (en) AT 10 (en) Anti-tetany substance 10 (en) Dihidrotaquisterol (en) Dihydrotachysterolum (en)
http://linked.open...drugbank/toxicity	Toxicity associated with dihydrotachysterol is similar to that seen with large doses of vitamin D. (en)
http://linked.open...nk/proteinBinding	>99% (en)
http://linked.open...ynthesisReference	von Werder, F.; U.S. Patent 2,228,491; January 14,1941; assigned to Winthrop Chemical Company, Inc. (en)
foaf:page	http://www.drugs.com/mtm/dihydrotachysterol.html http://www.rxlist.com/cgi/generic/dhtinten.htm
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http://linked.open...l/drug/hasATCCode	Dihydrotachysterol
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http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	67-96-9 (en)
http://linked.open...drugbank/category	(en)
http://linked.open...gbank/containedIn	Dihydrotachysterol powder
http://linked.open...k/Bioavailability	http://linked.opendata.cz/resource/drugbank/property/271B5FE3-363D-11E5-9242-09173F13E4C5
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http://linked.open...strongest-acidic-	http://linked.opendata.cz/resource/drugbank/property/271B5FDF-363D-11E5-9242-09173F13E4C5
http://linked.open...-strongest-basic-	http://linked.opendata.cz/resource/drugbank/property/271B5FE0-363D-11E5-9242-09173F13E4C5

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