About: Amoxicillin     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type
http://linked.open...gbank/description
  • A broad-spectrum semisynthetic antibiotic similar to ampicillin except that its resistance to gastric acid permits higher serum levels with oral administration. Amoxicillin is commonly prescribed with clauvanic acid (a beta lactamase inhibitor) as it is susceptible to beta-lacatamase degradation. [PubChem] (en)
http://linked.open...y/drugbank/dosage
http://linked.open...generalReferences
  • # Drawz SM, Bonomo RA: Three decades of beta-lactamase inhibitors. Clin Microbiol Rev. 2010 Jan;23(1):160-201. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/20065329 (en)
http://linked.open...gy/drugbank/group
  • approved (en)
http://linked.open...drugbank/halfLife
  • 61.3 minutes (en)
http://linked.open...ugbank/indication
  • For the treatment of infections of the ear, nose, and throat, the genitourinary tract, the skin and skin structure, and the lower respiratory tract due to susceptible (only b-lactamase-negative) strains of <i>Streptococcus</i> spp. (a- and b-hemolytic strains only), <i>S. pneumoniae</i>, <i>Staphylococcus</i> spp., <i>H. influenzae</i>, <i>E. coli</i>, <i>P. mirabilis</i>, or <i>E. faecalis</i>. Also for the treatment of acute, uncomplicated gonorrhea (ano-genital and urethral infections) due to <i>N. gonorrhoeae</i> (males and females). (en)
sameAs
Title
  • Amoxicillin (en)
adms:identifier
http://linked.open...mechanismOfAction
  • Amoxicillin binds to penicillin-binding protein 1A (PBP-1A) located inside the bacterial cell well. Penicillins acylate the penicillin-sensitive transpeptidase C-terminal domain by opening the lactam ring. This inactivation of the enzyme prevents the formation of a cross-link of two linear peptidoglycan strands, inhibiting the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that amoxicllin interferes with an autolysin inhibitor. (en)
http://linked.open...drugbank/packager
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