About: Ethinyl Estradiol

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	A semisynthetic alkylated estradiol with a 17-alpha-ethinyl substitution. It has high estrogenic potency when administered orally and is often used as the estrogenic component in oral contraceptives [PubChem]. Ethinyl estradiol is marketed mostly as a combination oral contraceptive under several brand names such as Alesse, Tri-Cyclen, Triphasil, and Yasmin. The FDA label includes a black box warning that states that combination oral contraceptives should not be used in women over 35 years old who smoke due to the increased risk of serious cardiovascular side effects. (en)
http://linked.open...generalReferences	# FDA label. (en)
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...drugbank/halfLife	36 +/- 13 hours (en)
http://linked.open...ugbank/indication	For treatment of moderate to severe vasomotor symptoms associated with the menopause, female hypogonadism, prostatic carcinoma-palliative therapy of advanced disease, breast cancer, as an oral contraceptive, and as emergency contraceptive. (en)
http://linked.open...bank/manufacturer	Clonmel Healthcare Ltd. DAVA Pharmaceuticals Boehringer ingelheim pharmaceuticals inc
sameAs	Ethinyl Estradiol
Title	Ethinyl Estradiol (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00977/identifier/chebi/4903 http://linked.opendata.cz/resource/drugbank/drug/DB00977/identifier/drugbank/DB00977 http://linked.opendata.cz/resource/drugbank/drug/DB00977/identifier/kegg-compound/C07534 http://linked.opendata.cz/resource/drugbank/drug/DB00977/identifier/kegg-drug/D00554 http://linked.opendata.cz/resource/drugbank/drug/DB00977/identifier/pharmgkb/PA449527 http://linked.opendata.cz/resource/drugbank/drug/DB00977/identifier/wikipedia/Ethinylestradiol
http://linked.open...mechanismOfAction	Estrogens diffuse into their target cells and interact with a protein receptor. Target cells include the female reproductive tract, the mammary gland, the hypothalamus, and the pituitary. Estrogens increase the hepatic synthesis of sex hormone binding globulin (SHBG), thyroid-binding globulin (TBG), and other serum proteins and suppress follicle-stimulating hormone (FSH) from the anterior pituitary. This cascade is initiated by initially binding to the estrogen receptors. The combination of an estrogen with a progestin suppresses the hypothalamic-pituitary system, decreasing the secretion of gonadotropin-releasing hormone (GnRH). (en)
http://linked.open...drugbank/packager	Amerisource Health Services Corp. Barr Pharmaceuticals Bayer Healthcare C.O. Truxton Inc. Cardent International Inc. Advanced Pharmaceutical Services Inc. Carestream Health Inc. Carlisle Laboratories Inc. Apotheca Inc. A-S Medication Solutions LLC Pharmaceutical Utilization Management Program VA Inc. Astellas Pharma Inc. Bryant Ranch Prepack C.O. Truxton Inc. Carlisle Laboratories Inc. Casa De Amigos Pharmacy Central Texas Community Health Centers
http://linked.open.../drugbank/synonym	Ethinylestradiol (en) 17 alpha-Ethinylestradiol (en) 17 alpha-Ethynylestradiol (en) 17 alpha-Ethynyloestradiol (en) 17-ethinyl-3,17-estradiol (en) 17-ethinyl-3,17-oestradiol (en) 17-ethinylestradiol (en) 17alpha-Ethinyl estradiol (en) 17α-ethynylestradiol (en) Ethinyl-Oestranol (en) Ethinylestriol (en) Ethinyloestradiol (en) Ethynyl estradiol (en) Ethynylestradiol (en) Ethynyloestradiol (en) Ethinylestradiolum (en) Etinilestradiol (en)
http://linked.open...drugbank/toxicity	Oral, mouse LD<sub>50</sub>: 1737 mg/kg. Symptoms of overdose include nausea and vomiting, and withdrawal bleeding may occur in females. The FDA label includes a black box warning that states that combination oral contraceptives with ethinyl estradiol should not be used in women over 35 years old who smoke due to the increased risk of serious cardiovascular side effects. (en)
http://linked.open.../drugbank/mixture	Ortho Ortho-Cept Ovcon Ovral Preven Quartette Quasense Seasonale Seasonique Select 1/35 Sronyx Synphasic Tri-Cyclen Tri-Cyclen Lo Triphasil Triquilar Yasmin Yasminelle Yaz Zarah Alesse Amethyst Apri Aviane Brevicon Cyclen Demulen Desogen Diane-35 Evra femhrt Oraqix Avamigran Beanta JINTELI Jolessa Cafegotamine Kariva Lessina Cafergot Sup Cafergot Tab Ergodryl Cap Lutera Lybrel Ericaf Fencafen Microgestin

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